Phenotypes associated with this allele

• Allele Symbol: Zfhx3⁺
• Allele Name: wild type
• Allele ID: MGI:2432803
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Zfhx3^tm1.2Jtd/Zfhx3^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:5446523
ht2	Zfhx3^Sci/Zfhx3^+	involves: BALB/cOlaHsd * C3H/HeH	MGI:2679576
cn3	Zfhx3^tm1.1Jtd/Zfhx3^+	involves: 129S6/SvEvTac	MGI:5661033
cn4	Zfhx3^tm1.1Jtd/Zfhx3^+ Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:5446521
cx5	Per2^tm1Jt/Per2^+ Zfhx3^Sci/Zfhx3^+	involves: 129S6/SvEvTac * BALB/cOlaHsd * C3H/HeH * C57BL/6J	MGI:5661032

Genotype
MGI:5446523

ht1

• Allelic Composition: Zfhx3^tm1.2Jtd/Zfhx3⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced body size of Zfhx3^tm1.2Jtd/Zfhx3⁺ mice

mortality/aging

premature death ( J:189563 )

• 20 of 70 mice die within 4 weeks of birth

postnatal lethality, incomplete penetrance ( J:189563 )

• 29 of 70 mice die within the first 48 hours after birth

• 20 of 70 mice die within 4 weeks of birth

reproductive system

abnormal fertility/fecundity ( J:189563 )

• mice exhibit prolonged conception time with only 2 pregnancies observed

growth/size/body

decreased body size ( J:189563 )

• at P10

decreased body weight ( J:189563 )

• at P10

behavior/neurological

abnormal eating behavior ( J:189563 )

• despite normal milk suckling, small mice require extended weaning

decreased locomotor activity ( J:189563 )

Genotype
MGI:2679576

ht2

• Allelic Composition: Zfhx3^Sci/Zfhx3⁺
• Genetic Background: involves: BALB/cOlaHsd * C3H/HeH

behavior/neurological

abnormal circadian behavior ( J:101896 )

• circadian amplitude is reduced

• some heterozygotes display elements of free-running even with light cues and the occurrence of this phenotype is not dependent on the presence or absence of Pde6b^rd1

shortened circadian behavior period ( J:101896 )

• about 50% of heterozygotes have a period less than 23 hours with the shortest period being 21.5 hours

arrhythmic circadian behavior persistence ( J:101896 )

• some heterozygotes display signs of arrhythmicity in constant darkness

abnormal circadian behavior phase ( J:101896 )

• some heterozygotes display an abnormal phase angle of entrainment

advanced circadian behavior phase ( J:101896 )

• the phase delay induced by a 15 minute pulse of light at circadian time 16 hours is reduced or absent in some heterozygotes

abnormal circardian behavior entrainment ( J:101896 )

• heterozygotes display incomplete re-entrainment when moved from constant dark back to light-dark cycles

Genotype
MGI:5661033

cn3

• Allelic Composition: Zfhx3^tm1.1Jtd/Zfhx3⁺
• Genetic Background: involves: 129S6/SvEvTac

behavior/neurological

prolonged circadian behavior period ( J:223990 )

• mice transduced with a virus expressing cre recombinase exhibit an approximate 1.5-hour circadian period lengthening in the suprachiasmatic nucleus

Genotype
MGI:5446521

cn4

• Allelic Composition: Zfhx3^tm1.1Jtd/Zfhx3⁺; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

mortality/aging

preweaning lethality, incomplete penetrance ( J:189563 )

• half of mice die by weaning

Genotype
MGI:5661032

cx5

• Allelic Composition: Per2^tm1Jt/Per2⁺; Zfhx3^Sci/Zfhx3⁺
• Genetic Background: involves: 129S6/SvEvTac * BALB/cOlaHsd * C3H/HeH * C57BL/6J

nervous system

abnormal hypothalamus physiology ( J:223990 )

• the suprachiasmatic nucleus has a shorter circadian period, the period distribution is broader, and relative amplitude error (RAE) is increased in individual neurons imaged across the suprachiasmatic nucleus circuit