All Phenotypes Etv4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Etv4⁺
wild type
MGI:2432633

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL	MGI:3849055
cx2	Etv1^tm1Tmj/Etv1^tm1Tmj Etv4^tm1Arbr/Etv4⁺	involves: 129S1/Sv	MGI:5506526
cx3	Etv1^tm2Tmj/Etv1⁺ Etv4^tm1Arbr/Etv4⁺	involves: 129S1/Sv	MGI:3621024
cx4	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1Hass/Etv5⁺	involves: 129S1/Sv	MGI:4415302

Allelic Composition	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1.1Xsun/Etv5^tm1.2Xsun Tg(T-cre)1Lwd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5^tm1.1Xsun mutation (2 available); any Etv5 mutation (271 available)
Etv5^tm1.2Xsun mutation (0 available); any Etv5 mutation (271 available)
Tg(T-cre)1Lwd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:149477 )

• in 6 of 8 mice

Allelic Composition	Etv1^tm1Tmj/Etv1^tm1Tmj Etv4^tm1Arbr/Etv4⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1^tm1Tmj mutation (0 available); any Etv1 mutation (46 available)
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased muscle spindle number ( J:197913 )

• hypaxial (body wall and intercostal) muscles lack Etv4-positive muscle spindles while axial muscles have 14% of muscle spindles relative to control; hindlimb muscles retain about 50% of Etv4-positive muscle spindles

decreased sensory neuron number ( J:197913 )

• hypaxial (body wall and intercostal) muscles lack vGlut1 (Slc17a7)-positive spindle-associated sensory endings (SSEs) at P0-3 while axial muscles retain about 3%; hindlimb muscles retain about 50% of Slc17a7-positive SSEs

abnormal proprioceptive neuron morphology ( J:197913 )

• significant muscle to muscle variation in proprioceptive sensory neuron innervation is observed

muscle

decreased muscle spindle number ( J:197913 )

Allelic Composition	Etv1^tm2Tmj/Etv1⁺ Etv4^tm1Arbr/Etv4⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1^tm2Tmj mutation (0 available); any Etv1 mutation (46 available)
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal somatic sensory system morphology ( J:107207 )

• the interosseous nerve is present but thinner than in wild-type mice

decreased pacinian corpuscle number ( J:107207 )

• 20% decrease in pacinian corpuscle numbers in the crus at P0-P1

small pacinian corpuscles ( J:107207 )

• remaining corpuscles are smaller than wild-type but structurally similar

Allelic Composition	Etv4^tm1Arbr/Etv4⁺ Etv5^tm1Hass/Etv5⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4^tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5^tm1Hass mutation (0 available); any Etv5 mutation (271 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:155594 )

• in 15% of mice

absent kidney ( J:155594 )

• in 8% of mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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