All Phenotypes Snap25<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Snap25⁺
wild type
MGI:2432122

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Snap25^tm1Mcw/Snap25⁺	B6N.Cg-Snap25^tm1Mcw	MGI:5774646
ht2	Snap25^tm1.1Hze/Snap25⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr	MGI:5484608
ht3	Snap25^{tm2.1(cre)Hze}/Snap25⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr	MGI:5508526
ht4	Snap25^Bdr/Snap25⁺	involves: BALB/cAnNCrl	MGI:5428448
ht5	Snap25^Bdr/Snap25⁺	involves: BALB/cAnNCrl * C3H/HeN	MGI:2175726

Allelic Composition	Snap25^tm1Mcw/Snap25⁺
Genetic Background	B6N.Cg-Snap25^tm1Mcw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap25^tm1Mcw mutation (1 available); any Snap25 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:227349 )

• mice exhibit a decrease of mean discrimination index in both the standard novel object recognition test and the virtual object recognition test indicating attentional deficit

• application of movement in the virtual object recognition test rescues the attention deficit

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:227349

Allelic Composition	Snap25^tm1.1Hze/Snap25⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap25^tm1.1Hze mutation (1 available); any Snap25 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:101977 )

• mice are viable and fertile with no reported gross physical or behavioral abnormalities

Allelic Composition	Snap25^{tm2.1(cre)Hze}/Snap25⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap25^{tm2.1(cre)Hze} mutation (1 available); any Snap25 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:146821 )

• mice are viable and fertile with no gross physical or behavioral abnormalities

Allelic Composition	Snap25^Bdr/Snap25⁺
Genetic Background	involves: BALB/cAnNCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap25^Bdr mutation (2 available); any Snap25 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:119733 )

N	• mice exhibit normal activity levels, startle response amplitude, anxiety-related behavior and spatial learning

ataxia ( J:119733 )

• at 4 weeks

impaired coordination ( J:119733 )

endocrine/exocrine glands

decreased glucagon secretion ( J:119733 )

• basal and stimulated

abnormal pancreatic beta cell physiology ( J:119733 )

• defective vesicle turnover and exocytosis after depletion of intermediate and readily releasable pools

decreased insulin secretion ( J:119733 )

• basal and stimulated

homeostasis/metabolism

decreased glucagon secretion ( J:119733 )

• basal and stimulated

decreased insulin secretion ( J:119733 )

• basal and stimulated

nervous system

abnormal miniature excitatory postsynaptic currents ( J:119733 )

• reduced frequency but not amplitude

decreased prepulse inhibition ( J:119733 )

decreased synaptic glutamate release ( J:119733 )

• sponataneous and evoked

taste/olfaction

taste/olfaction phenotype ( J:119733 )

N	• mice exhibit normal olfaction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:119733

Allelic Composition	Snap25^Bdr/Snap25⁺
Genetic Background	involves: BALB/cAnNCrl * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap25^Bdr mutation (2 available); any Snap25 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:63816 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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