Phenotypes associated with this allele

• Allele Symbol: Ski⁺
• Allele Name: wild type
• Allele ID: MGI:2432104
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ski^em1(IMPC)Bay/Ski^+	C57BL/6N-Ski^em1(IMPC)Bay/BayMmucd	MGI:7629098
ht2	Ski^tm1Cco/Ski^+	involves: 129P2/OlaHsd * Black Swiss	MGI:2653478
ht3	Ski^tm1Cco/Ski^+	involves: 129P2/OlaHsd * C57BL/6	MGI:2653477
cx4	Gli3^Xt-J/Gli3^Xt-J Ski^tm1Cco/Ski^+	involves: C3H * C57BL/6	MGI:2653485

Genotype
MGI:7629098

ht1

• Allelic Composition: Ski^em1(IMPC)Bay/Ski⁺
• Genetic Background: C57BL/6N-Ski^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Ski

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:211773 )

♂

IMPC - BCM

decreased locomotor activity ( J:211773 )

♀

IMPC - BCM

Genotype
MGI:2653478

ht2

• Allelic Composition: Ski^tm1Cco/Ski⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

craniofacial

midline facial cleft ( J:42573 )

• frontonasal clefting occasionally seen

nervous system

abnormal neural tube morphology ( J:42573 )

exencephaly ( J:42573 )

• occasional exencephally seen

embryo

abnormal neural tube morphology ( J:42573 )

growth/size/body

midline facial cleft ( J:42573 )

• frontonasal clefting occasionally seen

Genotype
MGI:2653477

ht3

• Allelic Composition: Ski^tm1Cco/Ski⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased incidence of tumors by chemical induction ( J:73349 )

• n addition to the phenotype observed for heterozygotes on a 129P2 and Black Swiss background, heterozygotes on this background display increased succeptibility for tumors when injected IP with 9,10-dimethyl-1,2-benzanthracene

increased lymphoma incidence ( J:73349 )

• the most frequent tumors to develop were malignant lymphomas

cellular

increased fibroblast proliferation ( J:73349 )

• In addition to the phenotype observed for heterozygotes on a 129P2 and Black Swiss background, heterozygotes on this background display increased rate of proliferation for MEF in culture

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:73349 )

• n addition to the phenotype observed for heterozygotes on a 129P2 and Black Swiss background, heterozygotes on this background display increased succeptibility for tumors when injected IP with 9,10-dimethyl-1,2-benzanthracene

Genotype
MGI:2653485

cx4

• Allelic Composition: Gli3^Xt-J/Gli3^Xt-J; Ski^tm1Cco/Ski⁺
• Genetic Background: involves: C3H * C57BL/6

limbs/digits/tail

polydactyly ( J:80205 )

• 3 or more extra digits are seen

skeleton

abnormal skeleton development ( J:80205 )