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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox11+
wild type
MGI:2431971
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
Tead2tm1Hssk/Tead2tm1Hssk 		involves: 129 * C57BL/6 * CBA * FVB/N MGI:5285372
cx2
 		Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4tm1.1Vlf 		involves: 129 * C57BL/6 * FVB/N MGI:5285371
cx3
 		Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+ 		involves: 129 * C57BL/6 * FVB/N MGI:5285373
cx4
 		Sox11tm1.2Vlf/Sox11+
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1.1Vlf/Sox4+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285380


Genotype
MGI:5285372
cx1
Allelic
Composition		 Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
Tead2tm1Hssk/Tead2tm1Hssk
Genetic
Background		 involves: 129 * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
double outlet right ventricle ( J:175338 )
• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes
ventricular septal defect ( J:175338 )
• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes

embryo
abnormal notochord morphology ( J:175338 )
• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice

skeleton
abnormal vertebrae morphology ( J:175338 )
• more severe and more frequent than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes




Genotype
MGI:5285371
cx2
Allelic
Composition		 Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system

cardiovascular system
failure of heart looping ( J:175338 )
• at E9.5, mice lack heart coiling unlike wild-type mice

craniofacial
abnormal pharyngeal arch mesenchyme morphology ( J:175338 )
• branchial arch mesenchyme is loose and small compared to in wild-type mice

embryo
abnormal pharyngeal arch mesenchyme morphology ( J:175338 )
• branchial arch mesenchyme is loose and small compared to in wild-type mice

growth/size/body
abnormal pharyngeal arch mesenchyme morphology ( J:175338 )
• branchial arch mesenchyme is loose and small compared to in wild-type mice
decreased embryo size ( J:175338 )
• at E9.5




Genotype
MGI:5285373
cx3
Allelic
Composition		 Sox11tm1.2Vlf/Sox11+
Sox4tm1.1Vlf/Sox4+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

skeleton
abnormal cranium morphology ( J:175338 )
• hypomineralized skull with wide sutures
abnormal sternebra morphology ( J:175338 )
• hypoplastic
• the last two or three sternebrae are misshapen and irregularly mineralized
abnormal xiphoid process morphology ( J:175338 )
• the xiphoid process is misshapen and irregularly mineralized
abnormal lumbar vertebrae morphology ( J:175338 )
• unfused lumbar vertebral bodies
• L4 and L5 are duplicated
abnormal bone mineralization ( J:175338 )
• hypomineralized skull
• the last two or three sternebrae and the xiphoid process are irregularly mineralized

cardiovascular system
ventricular septal defect ( J:175338 )
• incomplete ventricular septation

vision/eye
vision/eye phenotype ( J:175338 )
N
• mice exhibit normal eyes

craniofacial
craniofacial phenotype ( J:175338 )
N
• mice exhibit normal palate and lip formation
abnormal cranium morphology ( J:175338 )
• hypomineralized skull with wide sutures

hematopoietic system
small spleen ( J:175338 )
• in 60% of mice

immune system
small spleen ( J:175338 )
• in 60% of mice

growth/size/body
omphalocele ( J:175338 )
• in 50% of mice in one of 2 crosses




Genotype
MGI:5285380
cx4
Allelic
Composition		 Sox11tm1.2Vlf/Sox11+
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1.1Vlf/Sox4+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox12tm1.1Vlf mutation (0 available); any Sox12 mutation (11 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
ventricular septal defect ( J:175338 )
• incomplete ventricular septation

skeleton
abnormal cranium morphology ( J:175338 )
• hypomineralized skull
abnormal sternebra morphology ( J:175338 )
• fusion and /or deletion
• split sternal bars in all mice
abnormal vertebrae morphology ( J:175338 )
• vertebral body duplication in all mice
abnormal bone mineralization ( J:175338 )
• hypomineralized skull

craniofacial
abnormal cranium morphology ( J:175338 )
• hypomineralized skull

immune system
small spleen ( J:175338 )
• in all mice

hematopoietic system
small spleen ( J:175338 )
• in all mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory