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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ren1+
wild type
MGI:2431829
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ren1tm3Gom/Ren1+ 129S6/SvEvTac-Ren1tm3Gom MGI:3528017
ht2
 		Ren1tm1Tkh/Ren1+ C57BL/6-Ren1tm1Tkh MGI:3653330
cn3
 		Gnastm3Lsw/Gnastm3Lsw
Ren1tm2(cre)Gom/Ren1+ 		involves: 129S6/SvEvTac * Black Swiss MGI:3699334


Genotype
MGI:3528017
ht1
Allelic
Composition		 Ren1tm3Gom/Ren1+
Genetic
Background		 129S6/SvEvTac-Ren1tm3Gom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ren1tm3Gom mutation (0 available); any Ren1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating renin level ( J:95786 )
• in heterozygous females kidney and plasma renin concentrations are reduced to 60% and 10% of wild-type, respectively no significant difference is found between heterozygous and wild-type males

renal/urinary system
abnormal juxtaglomerular cell morphology ( J:95786 )
• fewer renin positive cells are seen in heterozygotes




Genotype
MGI:3653330
ht2
Allelic
Composition		 Ren1tm1Tkh/Ren1+
Genetic
Background		 C57BL/6-Ren1tm1Tkh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ren1tm1Tkh mutation (0 available); any Ren1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:110082 )
• normal blood pressure, plasma renin concentration, body weight, urinary output, urine chemistry, number of renin positive cells in the kidney, and kidney to body weight ratio




Genotype
MGI:3699334
cn3
Allelic
Composition		 Gnastm3Lsw/Gnastm3Lsw
Ren1tm2(cre)Gom/Ren1+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnastm3Lsw mutation (0 available); any Gnas mutation (53 available)
Ren1tm2(cre)Gom mutation (0 available); any Ren1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating renin level ( J:118076 )
• exhibit reduced basal levels of renin expression and very low plasma renin concentrations
decreased urine osmolality ( J:118076 )
• urine osmolarity is only slightly above isotonicity and significantly lower than in controls
increased urine prostaglandin level ( J:118076 )
• excretion of PGE2 in urine is significantly higher
abnormal renin activity ( J:118076 )
• acute stimulation of renin release in response to furosemide, hydralazine, and isoproterenol are abolished

renal/urinary system
decreased urine osmolality ( J:118076 )
• urine osmolarity is only slightly above isotonicity and significantly lower than in controls
increased urine prostaglandin level ( J:118076 )
• excretion of PGE2 in urine is significantly higher
abnormal kidney physiology ( J:118076 )
• renin release by juxtaglomerular cells is significantly lower

cardiovascular system
decreased mean systemic arterial blood pressure ( J:118076 )
• reduction in mean arterial blood pressure both at night and during the day




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory