Ren1^tm2(cre)Gom
Targeted Allele Detail

Summary

• Symbol: Ren1^tm2(cre)Gom
• Name: renin 1 structural; targeted mutation 2, R Ariel Gomez
• MGI ID: MGI:3044909
• Synonyms: Ren1^d, Ren1^dCre, Ren1^d-Cre
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm2(cre)Gom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90571
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ren1^tm2(cre)Gom expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ren1 (MGI:97898)

• Mutation details: Exons 1 through 7 were replaced by homologous recombination with a cassette containing cre and neo. Cre recombinase activity was confirmed in crosses with mice carrying floxed lacZ or GFP reporters. (J:90571)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ren1 (mouse) Summary of all recombinase alleles driven by Ren1. Comparative matrix view of recombinase activities Alliance mouse Ren1 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 36 strains or lines available

References

• Original: J:90571 Sequeira Lopez ML, et al., Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Dev Cell. 2004 May;6(5):719-28
• All: 33 reference(s)