Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rarg+ wild type MGI:2431795 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ventral extension of the cricoid cartilage is present in 2 of 11 heterozygotes
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• ventral extension of the cricoid cartilage is present in 2 of 11 heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 8% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2
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• 3% of mice have posterior spinous processes on V10 and sometimes V9
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• display a mild reduction of the palpebral aperture at E14.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 9% of mice have anterior tubercles that have shifted posteriorly to the seventh cervical vertebrae
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• 45% of mice exhibit possible transformation of the C2 vertebrae with slightly narrower C1 neural arches and/or a short cartilaginous ectopic anterior arch of the atlas on C2
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• 36% of mice have thick neural arches in the vertebrae
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• 27% of mice have posterior spinous processes on V10 and sometimes V9
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• 73% of mice have neural arch fusions of V1 to V4
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in all mice
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• a third cartilaginous pillar is fused ventrally to the basisphenoid bone to form a cartilaginous medial wall to the cavum epiptericum unlike in wild-type mice
• shortened braincase and compression by intracranial ectopic cartilaginous and bony nodules in non-exencephalic mice at E18.5
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• never closes
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• frequently fused to the incus, which is continuous with a rostrally oriented cartilaginous or osseous rod
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• dysplasia in some mice
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• in some mice
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• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone
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• larger than in wild-type mice
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• duplication of cartilaginous nasal septum
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• in 3 of 11 mice
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• in 2 of 11 mice
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• fusion of cervical neural arches in all mice
• dyssymphysis of cervical neural arches in 10 of 11 mice
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• in 9 of 11 mice
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• in 2 of 11 mice
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• in 5 of 11 mice
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• C2 to C1 in 7 of 11 mice
• C6 to C5 in 8 of 11 mice
• C7 to C6 in 8 of 11 mice
• C7 to T1 of T2 in 3 of 11 mice
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• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone
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• larger than in wild-type mice
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• in two exencephalic mice at E18.5
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• secondary to increased intracranial pressure caused by shortened braincase and compression by intracranial ectopic cartilaginous and bony nodules in 2 of 5 mice at E18.5
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• collapsed
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• failure of the rostral interhemispheric commissures (corpus callosum, hippocampal commissure and anterior commissure) in 2 of 5 mice at E18.5
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• small in two exencephalic mice at E18.5
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• in two exencephalic mice at E18.5
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• in two exencephalic mice at E18.5
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• ectopic cartilaginous and bony nodules at E18.5
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• in 4 of 12 mice
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• in 4 of 12 mice
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• in all mice
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• bilateral (1 of 5 mice) or unilateral (3 of 5 mice) cystic epithelial formations within the parenchyma
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• bilateral in 1 of 5 mice, unilateral in 3 of 5 mice
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• bilateral in 1 of 5 mice, unilateral in 3 of 5 mice
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• bilateral in 1 of 5 mice, unilateral in 3 of 5 mice
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• bilateral cystic dysplasia in 2 of 5 mice
• shortened in all mice
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• in all mice
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• in two exencephalic mice at E18.5
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• a third cartilaginous pillar is fused ventrally to the basisphenoid bone to form a cartilaginous medial wall to the cavum epiptericum unlike in wild-type mice
• shortened braincase and compression by intracranial ectopic cartilaginous and bony nodules in non-exencephalic mice at E18.5
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• never closes
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• in 2 of 11 mice
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• frequently fused to the incus, which is continuous with a rostrally oriented cartilaginous or osseous rod
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• dysplasia in some mice
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• in some mice
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• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone
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• larger than in wild-type mice
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• cleft of the median upper lip in some mice
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• duplication of cartilaginous nasal septum
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• bilateral (1 of 5 mice) or unilateral (3 of 5 mice) cystic epithelial formations within the parenchyma
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• bilateral in 1 of 5 mice, unilateral in 3 of 5 mice
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• bilateral in 1 of 5 mice, unilateral in 3 of 5 mice
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• bilateral in 1 of 5 mice, unilateral in 3 of 5 mice
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• bilateral cystic dysplasia in 2 of 5 mice
• shortened in all mice
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• dysplasia in some mice
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• in some mice
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• cleft of the median upper lip in some mice
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• duplication of cartilaginous nasal septum
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• duplication of cartilaginous nasal septum
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 of 12 mutants exhibit agenesis of the metoptic pillar
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• 4 of 12 mutants exhibit agenesis of the metoptic pillar
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• 5 of 6 E18.5 mutants show a bilateral persistent hyperplastic primary vitreous
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• 4 of 12 mutants exhibit agenesis of the metoptic pillar
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 5 of 6 E18.5 mutants show a bilateral persistent hyperplastic primary vitreous
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• 46% of mutants exhibit skeletal malformations
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• 1 of 13 (8%) mutants exhibit a posterior tubercle on the basioccipital bone
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• 1 of 13 (8%) exhibit sternum malformations
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• 3 of 13 (23%) of mutants exhibit fusion of C1-AA with C2 dens
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• 2 of 13 (15%) mutants exhibit a bifid C2
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• 1 of 13 (8%) mutants exhibit a posterior tubercle on the basioccipital bone
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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