Analysis Tools
vision/eye
 |
IMPC - UCD
|
|
|
IMPC - UCD
|
|
Allele Symbol Allele Name Allele ID |
Ptma+ wild type MGI:2431754 |
||||||||||||
| Summary |
2 genotypes
|
|
|
Data Sources
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
IMPC - UCD
|
|
|
IMPC - UCD
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice show no obsessive behavior in the marble burying test or depression-like behaviors in the forced swim and the tail suspension tests
|
|
• mice show impaired learning and memory in the step-through passive avoidance test and the KUROBOX test
|
|
• in the step-through passive avoidance test, mice show a significant increase in latency to enter into the dark chamber throughout the conditioning session relative to wild-type controls, suggesting increased freezing behavior upon exposure to the novel environment
• at 24 hr after conditioning, the step-through latency is significantly lower than that in wild-type controls in the retention trials, suggesting impaired learning and memory
|
|
• mice exhibit increased freezing behavior in the cued fear conditioning test without exposure to cued (tone) stimulus, but show no significant differences in tone-dependent freezing relative to wild-type controls
|
|
• mice show impaired spatial discrimination and poor exploratory behavior for foods in the KUROBOX test
|
|
• mice exhibit increased anxiety-like behaviors in the light/dark transition test and the novelty-induced hypophagia test
• however, the anxiogenic response is normal in the elevated plus-maze test
|
|
• in the open field test, mice show a significant reduction in total distance travelled, time spent in the center area, vertical activity, and stereotypic counts relative to wild-type controls
|
|
• mice show impaired adult neurogenesis in the dentate gyrus of the hippocampus
• in the subgranular zone (SGZ) of the dentate gyrus, the numbers of BrdU-positive cells and doublecortin-positive cells are significantly lower than those in wild-type controls, suggesting decreased neuronal cell proliferation
• however, total brain weight is normal
|
|
• in the subgranular zone (SGZ) of the dentate gyrus, the numbers of BrdU-positive cells and doublecortin-positive cells are significantly lower than those in wild-type controls, suggesting decreased neuronal cell proliferation
|
|
• mice show impaired adult neurogenesis in the dentate gyrus of the hippocampus
|
|
• at 30 min after theta burst stimulation, enhancement of field excitatory post-synaptic potential (fEPSP) is significantly declined in acute hippocampal slices, indicating that LTP induction is weaker than in wild-type controls
|
|
• mice exhibit impaired long-term potentiation induction in the CA1 subfield of hippocampal slices
|
|
• mice exhibit a significant decrease in body weight relative to wild-type controls
|
|
• mice exhibit a significant decrease in body temperature relative to wild-type controls
|
|
• mice show impaired adult neurogenesis in the dentate gyrus of the hippocampus
• in the subgranular zone (SGZ) of the dentate gyrus, the numbers of BrdU-positive cells and doublecortin-positive cells are significantly lower than those in wild-type controls, suggesting decreased neuronal cell proliferation
• however, total brain weight is normal
|
|
• in the subgranular zone (SGZ) of the dentate gyrus, the numbers of BrdU-positive cells and doublecortin-positive cells are significantly lower than those in wild-type controls, suggesting decreased neuronal cell proliferation
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/28/2024 MGI 6.13 |
|
|
|
||