All Phenotypes Ptgs2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptgs2⁺
wild type
MGI:2431750

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ptgs2^tm1Unc/Ptgs2⁺	B6.129P2-Ptgs2^tm1Unc	MGI:4366272
ht2	Ptgs2^tm1Unc/Ptgs2⁺	D1.129P2(B6J)-Ptgs2^tm1Unc	MGI:3603834
ht3	Ptgs2^tm1Unc/Ptgs2⁺	D1.129P2-Ptgs2^tm1Unc	MGI:4366266
ht4	Ptgs2^tm1Unc/Ptgs2⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:4366242
ht5	Ptgs2^tm1Unc/Ptgs2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:4366164
cx6	Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2⁺	involves: 129P2/OlaHsd * C57BL/6 * SKH1	MGI:4366348
cx7	Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3812385
cx8	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3812386
cx9	Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2⁺	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J	MGI:3603949
cx10	Ptgs2^tm1Jed/Ptgs2⁺ Stk11^tm1Tpm/Stk11⁺	involves: 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:3790958

Allelic Composition	Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	B6.129P2-Ptgs2^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased prostaglandin level ( J:67211 )

• following occlusion of the middle cerebral artery, mice exhibit an attenuated increase in cortical prostaglandin compared with similarly treated wild-type mice

decreased cerebral infarct size ( J:67211 )

• 96 hours after occlusion of the middle cerebral artery, infarct size is reduced 20% compared to in similarly treated wild-type mice

nervous system

decreased cerebral infarct size ( J:67211 )

• 96 hours after occlusion of the middle cerebral artery, infarct size is reduced 20% compared to in similarly treated wild-type mice

Allelic Composition	Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	D1.129P2(B6J)-Ptgs2^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased chemical nociceptive threshold ( J:64383 )

• heterozygous female mutants exhibit fewer writhing responses and decreased nociception in the acetic acid-induced stretch model of algesia

Allelic Composition	Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	D1.129P2-Ptgs2^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:102779 )

• mice fed a high fat and sucrose diet exhibit a 24% greater increase in body weight compared with similarly treated wild-type mice and a 34% increase compared with homozygotes

increased circulating insulin level ( J:102779 )

• in mice fed a high fat and sucrose diet compared to in similarly treated wild-type mice or homozygotes

increased circulating leptin level ( J:102779 )

• leptin serum levels are 336% higher in mice fed a high fat and sucrose diet compared to in similarly treated wild-type mice

increased prostaglandin level ( J:102779 )

• fat pad tissue from mice fed a high fat and sucrose diet exhibit a 2-fold increase in prostaglandin production compared with tissues from similarly treated wild-type mice

adipose tissue

decreased total fat pad weight ( J:102779 )

• mice fed a high fat and sucrose diet exhibit a 134% increase in fat pad weight compared to in similarly treated wild-type mice and 328% increase compared to in similarly treated homozygotes

abnormal adipose tissue physiology ( J:102779 )

• cultured adipose tissue from mice fed a high fat and sucrose diet exhibit increased leptin released compared with adipose tissue from similarly treated wild-type mice or homozygotes

growth/size/body

increased body weight ( J:102779 )

• at 7 to 8 weeks, mice fed breeder chow (10% fat) exhibit increased body weight compared with wild-type mice

• however, after 28 weeks mice exhibit normal body weights when fed breeder chow

increased susceptibility to diet-induced obesity ( J:102779 )

• mice fed a high fat and sucrose diet exhibit a 24% greater increase in body weight compared with similarly treated wild-type mice and a 34% increase compared with homozygotes

Allelic Composition	Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoclast differentiation ( J:124756 )

• cultured bone marrow treated with 1,25-dihydroxyvitamin D3 (1,25-D) produce 50% less TRAP+ mononuclear cells (osteoclast) than similarly treated wild-type bone marrow

homeostasis/metabolism

decreased prostaglandin level ( J:124756 )

• 1,25-dihydroxyvitamin D3 (1,25-D)-stimulated bone marrow cultures produce 62% lower prostaglandin levels compared with similarly treated wild-type cultures

immune system

abnormal osteoclast differentiation ( J:124756 )

• cultured bone marrow treated with 1,25-dihydroxyvitamin D3 (1,25-D) produce 50% less TRAP+ mononuclear cells (osteoclast) than similarly treated wild-type bone marrow

hematopoietic system

abnormal osteoclast differentiation ( J:124756 )

• cultured bone marrow treated with 1,25-dihydroxyvitamin D3 (1,25-D) produce 50% less TRAP+ mononuclear cells (osteoclast) than similarly treated wild-type bone marrow

cellular

abnormal osteoclast differentiation ( J:124756 )

• cultured bone marrow treated with 1,25-dihydroxyvitamin D3 (1,25-D) produce 50% less TRAP+ mononuclear cells (osteoclast) than similarly treated wild-type bone marrow

Allelic Composition	Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired febrile response ( J:54450 )

• LPS-treated mice fail to exhibit an increase in core body temperature unlike similarly treated wild-type mice

cardiovascular system

increased systemic arterial systolic blood pressure ( J:155373 )

• during the inactive day and active night, mice exhibit increased systolic blood pressure compared with wild-type mice

• however, stress induced changes in blood pressure are normal

Allelic Composition	Hr^hr/Hr^hr Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (18 available); any Hr mutation (89 available)
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by UV induction ( J:121635 )

• after 14 weeks of UV treatment, mice fail to develop tumors unlike similarly treated SKH mice and do not develop tumors until 24 weeks of treatment

• UV-treated mice exhibit a 65% reduction in tumor number and decreased tumor incidence compared with similarly treated wild-type mice

homeostasis/metabolism

decreased prostaglandin level ( J:121635 )

• 50% in the epidermis

decreased incidence of tumors by UV induction ( J:121635 )

• after 14 weeks of UV treatment, mice fail to develop tumors unlike similarly treated SKH mice and do not develop tumors until 24 weeks of treatment

• UV-treated mice exhibit a 65% reduction in tumor number and decreased tumor incidence compared with similarly treated wild-type mice

cellular

increased cell proliferation ( J:121635 )

• skin from UV-treated mice exhibits 50% less basal cell proliferation than in skin from similarly treated wild-type mice

Allelic Composition	Ptgs1^tm1Unc/Ptgs1⁺ Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)
Ptgs2^tm1Unc mutation (0 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

delayed parturition ( J:67208 )

• parturition is delayed

Allelic Composition	Ptgs1^tm1Unc/Ptgs1^tm1Unc Ptgs2^tm1Unc/Ptgs2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

delayed parturition ( J:67208 )

• parturition is delayed

Allelic Composition	Apc^tm1Mmt/Apc⁺ Ptgs2^tm1Jed/Ptgs2⁺
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Mmt mutation (0 available); any Apc mutation (152 available)
Ptgs2^tm1Jed mutation (1 available); any Ptgs2 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestine morphology ( J:36816 )

• at 10 weeks, double heterozygotes develop only ~34% of the polyp number detected in the intestinal tracts of mice heterozygous for Apc^tm1Mmt alone

colon polyps ( J:36816 )

• at 10 weeks, double heterozygotes exhibit only 1.5 1.9 colonic polyps versus 6.8 7.2 detected in mice heterozygous for Apc^tm1Mmt alone

Allelic Composition	Ptgs2^tm1Jed/Ptgs2⁺ Stk11^tm1Tpm/Stk11⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs2^tm1Jed mutation (1 available); any Ptgs2 mutation (68 available)
Stk11^tm1Tpm mutation (0 available); any Stk11 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

gastric polyps ( J:93361 )

• large polyps (>2 mm) are reduced in number compared to Stk11 heterozygotes at 8.5 months

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