Analysis Tools|
Allele Symbol Allele Name Allele ID |
Plcg2+ wild type MGI:2431722 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• foot pads are swollen due to inflammation
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• foot pads are swollen due to inflammation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number
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• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells
• anti-DNA antibodies were not detected
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• mice have normal paws at birth but gradually develop swollen and deformed
• male mice were affected earlier at 2 months than female at 8-10 months
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• resulting in severe arthritis of the small joints of the paws and missing phalanges
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• in the superficial layers of the skin of the paws and ears
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• resulting in severe arthritis of the small joints of the paws and missing phalanges
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• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number
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• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells
• anti-DNA antibodies were not detected
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• in the superficial layers of the skin of the paws and ears
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice exhibit decreased TNF secretion in response to Toll-like receptor (TLR) ligands poly(I:C) (TLR3) and R848 (TLR7/8)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no chronic inflammation of the paw was observed
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• 28% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype
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• in three out of ten
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• in three out of ten
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• 28% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• the distribution of B cell subsets in the peritoneal cavity is normal
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• compared with Ightm1.1Twin homozygotes
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• compared with Ightm1.1Twin homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 40% of B cells are dead after 2 hours in culture with 50% after 4 hours and 70% dead after 6 hours
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• splenic B cell numbers are reduced to 13.5% of lymphocytes
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• there is a 4.3 fold decrease in the concentration of calcium fluxed intracellularly after stimulus compared to wild-type controls
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• 40% of B cells are dead after 2 hours in culture with 50% after 4 hours and 70% dead after 6 hours
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• splenic B cell numbers are reduced to 13.5% of lymphocytes
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• there is a 4.3 fold decrease in the concentration of calcium fluxed intracellularly after stimulus compared to wild-type controls
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• 40% of B cells are dead after 2 hours in culture with 50% after 4 hours and 70% dead after 6 hours
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• approximately 70% of homozygous mice developed despite absence of B and T cells
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• resulting in severe arthritis of the small joints of the paws and missing phalanges
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• in the superficial layers of the skin of the paws and ears
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• resulting in severe arthritis of the small joints of the paws and missing phalanges
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• in the superficial layers of the skin of the paws and ears
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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