Plcg2^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Plcg2^M2Btlr
• Name: phospholipase C, gamma 2; mutation 2, Bruce Beutler
• MGI ID: MGI:5619131
• Synonyms: Poseidon
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion at base pair 117,615,238 (v38) on chromosome 8, or base pair 116,948 in the GenBank genomic region NC_000074 encoding Plcg2. The mutation corresponds to residue 3,532 in the mRNA sequence NM_172285 within exon 4 of 33 total exons. The mutation results in a tryptophan (W) to arginine (R) substitution at position 1113 (W1113R) in the phospholipase C gamma 2 (PLCgamma-2) protein. (J:218966)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 73 strains or lines available

References

• Original: J:218966 SoRelle J, et al., Mutagenetix entry for Poseidon. MGI Direct Data Submission. 2015
• All: 1 reference(s)