All Phenotypes Pfn1<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pfn1⁺
wild type
MGI:2431684

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pfn1^tm1Wit/Pfn1⁺	B6.129S4-Pfn1^tm1Wit	MGI:2669618
ht2	Pfn1^{tm1a(EUCOMM)Wtsi}/Pfn1⁺	B6Brd;B6Dnk;B6N-Tyr^c-Brd Pfn1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5706060
ht3	Pfn1^tm1Fgi/Pfn1⁺	involves: 129P2/OlaHsd	MGI:7482605
ht4	Pfn1^tm1Wit/Pfn1⁺	involves: 129S4/SvJae * BALB/c	MGI:2669613
ht5	Pfn1^tm1Wit/Pfn1⁺	involves: 129S4/SvJae * C57BL/6	MGI:2669615
cx6	Ldlr^tm1Her/Ldlr^tm1Her Pfn1^tm1Wit/Pfn1⁺	B6.129S-Ldlr^tm1Her Pfn1^tm1Wit	MGI:4367099
cx7	Enah^tm1Fbg/Enah^tm1Fbg Pfn1^tm1Wit/Pfn1⁺	involves: 129S4/SvJae	MGI:3718223

Allelic Composition	Pfn1^tm1Wit/Pfn1⁺
Genetic Background	B6.129S4-Pfn1^tm1Wit

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1^tm1Wit mutation (0 available); any Pfn1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:77643 )

• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates

prenatal lethality, incomplete penetrance ( J:77643 )

• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes

Allelic Composition	Pfn1^{tm1a(EUCOMM)Wtsi}/Pfn1⁺
Genetic Background	B6Brd;B6Dnk;B6N-Tyr^c-Brd Pfn1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0046_1_C10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Pfn1 mutation (10 available)

Data Sources

IMPC Data for Pfn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:175295 )

IMPC - WTSI

increased circulating magnesium level ( J:211773 )

IMPC - WTSI

increased circulating amylase level ( J:211773 )

IMPC - WTSI

improved glucose tolerance ( J:211773 )

IMPC - WTSI

skeleton

decreased bone mineral content ( J:175295 )

IMPC - WTSI

vision/eye

abnormal cornea morphology ( J:211773 )

IMPC - WTSI

cornea opacity ( J:211773 )

IMPC - WTSI

fused cornea and lens ( J:211773 )

IMPC - WTSI

Allelic Composition	Pfn1^tm1Fgi/Pfn1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1^tm1Fgi mutation (0 available); any Pfn1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:335495 )

• abnormal rounding of MEFs during mitosis

increased cell nucleus count ( J:335495 )

• some trinucleated calvaria mesenchymal cells from newborns and femur growth plate at age 4 months

binucleate ( J:335495 )

• 5x increase in binucleated cells in femur growth plate at age 4 months

increased micronucleus incidence ( J:335495 )

• increased frequency of micronuclei in calvaria mesenchymal cells from newborns

abnormal mitotic cytokinesis ( J:335495 )

• in MEFs

Allelic Composition	Pfn1^tm1Wit/Pfn1⁺
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1^tm1Wit mutation (0 available); any Pfn1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:77643 )

• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates

prenatal lethality, incomplete penetrance ( J:77643 )

• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes

Allelic Composition	Pfn1^tm1Wit/Pfn1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn1^tm1Wit mutation (0 available); any Pfn1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:77643 )

• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates

prenatal lethality, incomplete penetrance ( J:77643 )

• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Pfn1^tm1Wit/Pfn1⁺
Genetic Background	B6.129S-Ldlr^tm1Her Pfn1^tm1Wit

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (21 available); any Ldlr mutation (78 available)
Pfn1^tm1Wit mutation (0 available); any Pfn1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:140294 )

• produced at a lower than expected ratio

• mice surviving to adulthood are healthy and normal regardless of diet fed

cardiovascular system

atherosclerotic lesions ( J:140294 )

• lesions are reduced by 60% in males and 75% in females after 2 months on a high cholesterol diet as compared to Ldlr deficient mice

• less area in lesions is occupied by macrophage

• macrophage recruitment to lesion sites is reduced early in lesion formation

immune system

impaired macrophage chemotaxis ( J:140294 )

• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation

• ess area in lesions is occupied by macrophage

cellular

impaired macrophage chemotaxis ( J:140294 )

• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation

• ess area in lesions is occupied by macrophage

hematopoietic system

impaired macrophage chemotaxis ( J:140294 )

• macrophage recruitment to atherosclerotic lesion sites is reduced early in lesion formation

• ess area in lesions is occupied by macrophage

Allelic Composition	Enah^tm1Fbg/Enah^tm1Fbg Pfn1^tm1Wit/Pfn1⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enah^tm1Fbg mutation (0 available); any Enah mutation (208 available)
Pfn1^tm1Wit mutation (0 available); any Pfn1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:53259 )

• no viable animals of expected genotype from double heterozygous cross

• present in expected Mendelian frequencies at E9.5 and E16

embryo

decreased embryo size ( J:53259 )

• at E9.5

incomplete rostral neuropore closure ( J:53259 )

• cephalic neural tube failed to close in half of embryo

growth/size/body

decreased embryo size ( J:53259 )

• at E9.5

nervous system

incomplete rostral neuropore closure ( J:53259 )

• cephalic neural tube failed to close in half of embryo

anencephaly ( J:53259 )

• at E16.5 in 1 of 9 embryos

exencephaly ( J:53259 )

• at E16.5 in 4 of 9 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24