Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ntrk2+ wild type MGI:2431646 |
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| Summary |
11 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice spend less time and make fewer entries into the middle of an open field test
• mice spend less than two-thirds of the time as controls in the open arms of elevated plus maze test
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - HAR
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IMPC - HAR
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IMPC - HAR
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IMPC - HAR
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mature mice (2-3 months) become obese
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| N |
• no difference in cumulative food intake by 7 month-old mice is observed during a 3 week period
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• elevated in older (5 months) mice
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• elevated in older (5 months) mice
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• ACTH levels are significantly elevated in 5 month animals at 4pm relative to controls
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• thicker at 5 months
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• at 5 months
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• mice show increase hepatic lipid accumulation compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no significant weight difference compared to controls is observed
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| N |
• no adrenal hypertrophy is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• motor axonal regeneration is increased in the tibial nerve cross-suture but reaches an early plateau with only 50% of nerves regenerating between 3 and 8 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in wild-type mice but fewer than in Ntrk2tm1Lfr heterozygotes
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• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in wild-type mice but fewer than in Ntrk2tm1Lfr heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• abnormal rebound of corticosterone levels following dexamethasone
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• evening levels are decreased
• levels are raised by stress but lower compared to controls 1 h after stress
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• levels are reduced by about 25%
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• evening levels are decreased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an increase in the proportion of Adelta low-threshold mechanoreceptors and decreased proportion of Abeta slowly adapting low-threshold mechanoreceptors compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a modest inhibition of kindling development is seen with an increased number of stimulations required to induce the third consecutive class 4 or class 5 seizure
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• a modest inhibition of kindling development is seen with an increased number of stimulations required to induce the third consecutive class 4 or class 5 seizure
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls
• male mice also have a significantly increased number of biting attacks over a 5 minute period
• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnftm1Par mutant allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• the Ntrk2tm1.1Tes allele rescues the increased apoptosis of cortical cells in vivo, and the accelerated death of hippocampal neurons in vitro that occurs with cells carrying the Rb(12.Ts171665Dn)2Cje allele
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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