About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mog+
wild type
MGI:2431533
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak 		involves: 129S2/SvPas * C57BL/6 MGI:3690542
cn2
 		Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+ 		involves: C57BL/6 MGI:3690541
cn3
 		Faddtm1Mpa/Faddtm1Mpa
Mogtm1(cre)Gkl/Mog+ 		involves: C57BL/6 * SJL MGI:4880724


Genotype
MGI:3690542
cn1
Allelic
Composition		 Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Cgn mutation (1 available); any Fas mutation (82 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (56 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:114741 )
N
• B and T cell distribution in the lymph nodes is normal
• the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )
• mice are almost completely resistant to induction of experimental autoimmune encephalomyelitis (EAE) by injection of MOG p35-55
• almost no oligodendrocyte apoptosis after EAE induction unlike in wild-type mice
• reduction in demyelination and inflammation after induction of EAE is greater than in mutant mice wild-type for Tnfrsf1a
• 24 days after induction of EAE, minimal axonal injury is seen in spinal cords




Genotype
MGI:3690541
cn2
Allelic
Composition		 Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Cgn mutation (1 available); any Fas mutation (82 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:114741 )
N
• the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )
• reduction in the onset and severity, but not incidence, of experimental autoimmune encephalomyelitis (EAE) induced by injection of MOG p35-55
• demyelination induced by injection of MOG p35-55 is reduced by about 70% compared to wild-type
• perivascular and parenchymal infiltration by T lymphocytes and macrophages is also reduced after induction of EAE
• mild reduction in oligodendrocyte apoptosis after EAE induction




Genotype
MGI:4880724
cn3
Allelic
Composition		 Faddtm1Mpa/Faddtm1Mpa
Mogtm1(cre)Gkl/Mog+
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Mpa mutation (0 available); any Fadd mutation (18 available)
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:167475 )
N
• peripheral T cell activation is normal
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:167475 )
• MOG35-55-treated mice exhibit less severe disease and reduced oligodendrocyte apoptosis compared with similarly treated wild-type mice
• however, MOG35-55-treated mice exhibit normal T cell activation

nervous system
nervous system phenotype ( J:167475 )
N
• mice exhibit normal myelination
abnormal oligodendrocyte apoptosis ( J:167475 )
• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice

cellular
abnormal oligodendrocyte apoptosis ( J:167475 )
• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice
• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory