Phenotypes associated with this allele

• Allele Symbol: Met⁺
• Allele Name: wild type
• Allele ID: MGI:2431383
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Met^tm5Gvw/Met^+	involves: 129 * C57BL/6J	MGI:3710086
ht2	Met^tm1Gvw/Met^+	involves: 129 * C57BL/6J	MGI:3521979
ht3	Met^tm2Gvw/Met^+	involves: 129 * C57BL/6J	MGI:3521982
ht4	Met^tm4Gvw/Met^+	involves: 129 * C57BL/6J	MGI:3521988
ht5	Met^tm4Gvw/Met^+	involves: 129 * C57BL/6J * FVB/N	MGI:5565367
ht6	Met^tm1Cbm/Met^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3617779
ht7	Met^Par4/Met^+	involves: BALB/cJ * SWR/J	MGI:2175544
cx8	Met^tm1Cpo/Met^+ Pax3^tm2.1(PAX3/FOXO1A)Buck/Pax3^+	involves: 129 * BALB/c * C57BL/6	MGI:3690114
cx9	Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met^+	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	MGI:3759969
cx10	Cd44^tm1Mak/Cd44^tm1Mak Met^tm1Cbm/Met^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4946521

Genotype
MGI:3710086

ht1

• Allelic Composition: Met^tm5Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:94722 )

N • mice survive a normal lifespan of 20.5+/-4.7 months compared to wild-type mice that survive 22.1+/-4.3 months

neoplasm

neoplasm ( J:94722 )

N • mice are controls for loci insertion and have a tumor incidences of 1 histiocytic sarcomas, 2 lymphoblastic lymphomas, 1 lung adenocarcinoma, 1 lung adenoma and 4 nonremarkable tumors or lesions per 18 mice examined

Genotype
MGI:3521979

ht2

• Allelic Composition: Met^tm1Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased tumor incidence ( J:94722 )

• 58.8% tumor incidence compared to 44.4% in controls, with some developing multiple cancers

increased lymphoma incidence ( J:94722 )

• increased incidence of lymphomas, especially histiocytic sarcomas

increased histiocytic sarcoma incidence ( J:94722 )

increased carcinoma incidence ( J:94722 )

• increased incidence of various carcinomas including transitional cell and squamous cell carcinoma

increased squamous cell carcinoma incidence ( J:94722 )

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors

immune system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

renal/urinary system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

hydronephrosis ( J:94722 )

• infrequent to moderate incidence of hydronephrosis

Genotype
MGI:3521982

ht3

• Allelic Composition: Met^tm2Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

premature death ( J:94722 )

• shorter lifespan (15.9 months) compared to controls (20.5 months)

neoplasm

increased tumor incidence ( J:94722 )

• 89.5% tumor incidence compared to 44.4% in controls, with some developing multiple cancers

increased lymphoma incidence ( J:94722 )

• 32% developed lymphomas, mainly histiocytic sarcomas

increased histiocytic sarcoma incidence ( J:94722 )

increased hemangiosarcoma incidence ( J:94722 )

• 63% developed sarcomas, mainly hemangiosarcomas

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors

immune system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

renal/urinary system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

hydronephrosis ( J:94722 )

• infrequent to moderate incidence of hydronephrosis

Genotype
MGI:3521988

ht4

• Allelic Composition: Met^tm4Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J

neoplasm

increased tumor incidence ( J:94722 )

• 50% tumor incidence compared to 44.4% in controls

increased lymphoma incidence ( J:94722 )

increased sarcoma incidence ( J:94722 )

• developed various sarcomas

cellular

chromosome breakage ( J:94722 )

• trisomy and tetrasomy of chromosome 6 and duplication of the mutant Met allele were observed in tumors

immune system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

renal/urinary system

glomerulonephritis ( J:94722 )

• infrequent to moderate incidence of glomerulonephritis

hydronephrosis ( J:94722 )

• infrequent to moderate incidence of hydronephrosis

Genotype
MGI:5565367

ht5

• Allelic Composition: Met^tm4Gvw/Met⁺
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

increased squamous cell carcinoma incidence ( J:151890 )

♀ • mammary squamous cell carcinoma

increased sarcoma incidence ( J:151890 )

♀ • undifferentiated mammary sarcomas

increased hemangiosarcoma incidence ( J:151890 )

♀ • mammary hamangiosarcoma

increased myoepithelioma incidence ( J:151890 )

♀ • mammary myoepithelioma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

integument

increased mammary gland tumor incidence ( J:151890 )

♀ • both nulliparous and multiparous females develop mammary tumors with high penetrance

♀ • mammary pads from 6- to 8-month old females show no evidence of preneoplastic growth, indicating that tumor growth is extremely rapid after initiation

♀ • mammary tumors show diverse histology with basal characteristics and include mammary adenosquamous carcinoma with solid and tubular patterns, mammary squamous cell carcinoma, mammary myoepithelioma, hamangiosarcoma, mammary adenocarcinoma with squamous metaplasia

♀ • solid features are present in 30% of tumors, but in several cases, the solid phenotype is intermixed with squamous metaplastic cells

♀ • significant squamous metaplasia is seen in 65% of mammary tumors

♀ • tumors are often estrogen receptor-positive and progesterone receptor-negative

increased mammary adenocarcinoma incidence ( J:151890 )

♀ • mammary adenocarcinoma with squamous metaplasia or/and with solid patterns

♀ • mammary adenocarcinomas show high levels of Met amplification and trisomy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:151890

Genotype
MGI:3617779

ht6

• Allelic Composition: Met^tm1Cbm/Met⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

digestive/alimentary system

abnormal tongue morphology ( J:28570 )

• at E10.5 or E12.5, a reduction in the number of myogenin expressing cells is seen in the developing tongue

craniofacial

abnormal tongue morphology ( J:28570 )

• at E10.5 or E12.5, a reduction in the number of myogenin expressing cells is seen in the developing tongue

growth/size/body

abnormal tongue morphology ( J:28570 )

• at E10.5 or E12.5, a reduction in the number of myogenin expressing cells is seen in the developing tongue

Genotype
MGI:2175544

ht7

• Allelic Composition: Met^Par4/Met⁺
• Genetic Background: involves: BALB/cJ * SWR/J

neoplasm

decreased lung tumor incidence ( J:43176 )

• lung tumor resistance

respiratory system

decreased lung tumor incidence ( J:43176 )

• lung tumor resistance

Genotype
MGI:3690114

cx8

• Allelic Composition: Met^tm1Cpo/Met⁺; Pax3^{tm2.1(PAX3/FOXO1A)Buck}/Pax3⁺
• Genetic Background: involves: 129 * BALB/c * C57BL/6

embryo

embryo phenotype ( J:86911 )

N • ectopic somite delamination is not seen, unlike in Pax3^{tm2.1(PAX3/FOXO1A)Buck} single heterozygotes

Genotype
MGI:3759969

cx9

• Allelic Composition: Gab1^tm3Wbm/Gab1^tm3Wbm; Met^tm1Cbm/Met⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Cleft palate in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm, Gab1^tm1Wbm/Gab1^tm1Wbm and Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ mice, but not in Gab1^tm4Wbm/Gab1^tm4Wbm mice

craniofacial

cleft secondary palate ( J:125303 )

• incidences of cleft palate are enhanced compared to in Gab1^tm3Wbm homozygotes

digestive/alimentary system

cleft secondary palate ( J:125303 )

• incidences of cleft palate are enhanced compared to in Gab1^tm3Wbm homozygotes

growth/size/body

cleft secondary palate ( J:125303 )

• incidences of cleft palate are enhanced compared to in Gab1^tm3Wbm homozygotes

Genotype
MGI:4946521

cx10

• Allelic Composition: Cd44^tm1Mak/Cd44^tm1Mak; Met^tm1Cbm/Met⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

neonatal lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

respiratory system

primary atelectasis ( J:128984 )

• multifocal atelectasis in the lung caused by a primary asphyxia

• in 76% of the mutant animals, the lungs sank, indicating that they are not inflated

respiratory distress ( J:128984 )

• shortly after birth, 70% of the animals die of breathing difficulties

nervous system

abnormal phrenic nerve morphology ( J:128984 )

• individual Schwann cell profiles ensheath more axons than in control mice

• less Schwann cell profiles than in controls ensheath only one axon

• increased number of Schwann cells associated with bundles of axons without intervening Schwann cell processes

• reduced number of segregated axons

• decreased percentage of segregated axons with a diameter size between 0.75 to 1.00 um

• slightly increased percentage of small (<0.75 um) and large (>1.00 um) caliber axons

abnormal miniature excitatory postsynaptic currents ( J:128984 )

• even more severe impairment of excitatory synaptic transmission in preBotC neurons

• decreased frequency of glutamatergic mEPSCs in preBotC neurons, compare with Cd44^tm1Mak homozygous mice

• moderately decreased amplitude

abnormal miniature inhibitory postsynaptic currents ( J:128984 )

• reduced spontaneous postsynaptic currents (sPSCs) in preBotC neurons

• amplitudes are not changed

decreased miniature inhibitory postsynaptic current frequency ( J:128984 )

• decreased frequency of glycinergic and GABAergic miniature mIPSCs in preBotC neurons