Analysis Tools|
Allele Symbol Allele Name Allele ID |
Il13+ wild type MGI:2431088 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the lungs of mice infected with N. brasiliensis
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• mice exhibit reduced helminthes Nippostrongylus brasiliensis expulsion compared with control mice
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• in the lungs of mice infected with N. brasiliensis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the lungs of mice infected with N. brasiliensis
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• mice exhibit reduced helminth Nippostrongylus brasiliensis expulsion compared with control mice
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• in the lungs of mice infected with N. brasiliensis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
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• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
|
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• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• F1 crosses between mice homozygote for either allele creates offspring that has only one functional Il13 allele that is in cis with Il4tm1.1Wep GFP reporter allele
• conversely, the one functional, wild-type Il4 allele is in cis with the null Il13tm1Anjm allele
• CD4+ T cells from these mice primed in vitro under Th2 conditions have only 4.5% of T cells producing IL-4 compared to 14.8% of T cells producing IL-4 that are homozygous for wild-type Il13 and heterozygote for Il4tm1.1Wep allele
• in contrast, GFP expression is similar in primed T cells from both sets of mice (5.9% and 6.8%)
• F1 crosses between 129 mice and Il4tm1.1Wep homozygotes demonstrated the diminished IL-4 secretion was not the result of 129 polymorphisms in the Il4-Il13 genomic region
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
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• decreased Nuocytes after infection with the helminth parasite N. brasiliensis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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