All Phenotypes Hoxb2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb2⁺
wild type
MGI:2430907

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxb2^tm1Mrc/Hoxb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3722149
ht2	Hoxb2^tm3.1Fmr/Hoxb2⁺	involves: 129S2/SvPas * C57BL/6	MGI:5491191
cx3	Hoxb2^tm1Mrc/Hoxb2⁺ Hoxb4^tm1Nrm/Hoxb4⁺	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:3722150

Allelic Composition	Hoxb2^tm1Mrc/Hoxb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb2^tm1Mrc mutation (0 available); any Hoxb2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

misaligned sternebrae ( J:37682 )

• two mice of 39 had sternebrae that were not properly aligned along the ventral midline

abnormal arcus anterior morphology ( J:37682 )

• in 41% of mice the anterior arch is slanted rostrally

cervical vertebral transformation ( J:37682 )

• in 13% of mice a C2 to C1 transformation occurs

nervous system

abnormal facial nerve morphology ( J:37682 )

• reduction in the facial nerve is not as severe as in homozygotes

Allelic Composition	Hoxb2^tm3.1Fmr/Hoxb2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb2^tm3.1Fmr mutation (0 available); any Hoxb2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:197162 )

• mice are produced at normal Mendelian frequencies, display no obvious abnormalities, are fertile, and have normal lifespans

Allelic Composition	Hoxb2^tm1Mrc/Hoxb2⁺ Hoxb4^tm1Nrm/Hoxb4⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb2^tm1Mrc mutation (0 available); any Hoxb2 mutation (11 available)
Hoxb4^tm1Nrm mutation (0 available); any Hoxb4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:37682 )

• 6 of 9 mice die at birth

skeleton

abnormal sternebra morphology ( J:37682 )

• sternal defects are intermediate between Hoxb2^tm1Mrc and Hoxb4^tm1Nrm homozygotes

• 3 of 9 mice lacked the pericardial fold covering the gap between sternal bands

cervical vertebral transformation ( J:37682 )

• 7 of 8 mice have C2 to C1 transformation

respiratory system

respiratory distress ( J:37682 )

• the remaining 3 of 9 mice exhibit respiratory distress

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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