Phenotypes associated with this allele

• Allele Symbol: Hmga1⁺
• Allele Name: wild type
• Allele ID: MGI:2430898
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hmga1^tm2b(EUCOMM)Hmgu/Hmga1^+	C57BL/6N-Hmga1^tm2b(EUCOMM)Hmgu/Bay	MGI:5767686
ht2	Hmga1^tm1Cha/Hmga1^+	chimera involves: 129S1/Sv * C57BL/6J	MGI:2673335
ht3	Hmga1^tm1Afus/Hmga1^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3621548
ht4	Hmga1^tm1Brun/Hmga1^+	Not Specified	MGI:3583952

Genotype
MGI:5767686

ht1

• Allelic Composition: Hmga1^{tm2b(EUCOMM)Hmgu}/Hmga1⁺
• Genetic Background: C57BL/6N-Hmga1^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0795_1_B09

Data Sources

IMPC Data for Hmga1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

vision/eye

decreased total retina thickness ( J:211773 )

♂

IMPC - BCM

Genotype
MGI:2673335

ht2

• Allelic Composition: Hmga1^tm1Cha/Hmga1⁺
• Genetic Background: chimera involves: 129S1/Sv * C57BL/6J

reproductive system

decreased male germ cell number ( J:84851 )

♂ • a partial to total deficiency of male germ cells was observed within some chimeric seminiferous tubules

abnormal seminiferous tubule morphology ( J:84851 )

♂ • sterile chimeric mice with >70% chimerism displayed more than 10% abnormal seminiferous tubules whereas a fertile chimera with 40% chimerism displayed less aberrant tubules

abnormal seminiferous tubule epithelium morphology ( J:84851 )

♂ • chimeric mice with >70% chimerism displayed absence of normal seminiferous epithelia

abnormal Sertoli cell morphology ( J:84851 )

♂ • Sertoli cells found within chimeric seminiferous tubules that lacked all germ cells appeared vacuolated

small seminiferous tubules ( J:84851 )

♂ • chimeric seminiferous tubules with a 3% to 100% germ cell depletion displayed smaller than average tubule diameters

small testis ( J:84851 )

♂ • at 5-8 months of age, chimeric testes were grossly reduced in size relative to wild-type testes

abnormal spermatogenesis ( J:84851 )

♂ • no sperm carrying the disrupted allele were identified; all mature sperm obtained from heterozygous chimeras were derived from wild-type spermatocytes

♂ • a sterile chimeric mouse with 90% chimerism showed complete absence of spermatocytes in >70% of aberrant seminiferous tubules, and only a few undifferentiated germ cells (spermatogonia) in the remaining (30%) tubules

azoospermia ( J:84851 )

♂ • a sterile chimeric mouse with 90% chimerism showed complete absence of mature sperm in the epididymis, consistent with the finding that even the few germ cells found in the remaining (30%) aberrant regions of seminiferous tubules failed to develop to term

small epididymis ( J:84851 )

♂ • at 5-8 months of age, chimeric epididymides were grossly reduced in size relative to wild-type epididymides

male infertility ( J:84851 )

♂ • o none of the chimeric mice produced agouti (ES cell derived) progeny; 4 of 14 chimeras with a degree of chimerism greater than 70% were completely sterile

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:84851 )

♂ • sterile chimeric mice with >70% chimerism displayed more than 10% abnormal seminiferous tubules whereas a fertile chimera with 40% chimerism displayed less aberrant tubules

abnormal seminiferous tubule epithelium morphology ( J:84851 )

♂ • chimeric mice with >70% chimerism displayed absence of normal seminiferous epithelia

abnormal Sertoli cell morphology ( J:84851 )

♂ • Sertoli cells found within chimeric seminiferous tubules that lacked all germ cells appeared vacuolated

small seminiferous tubules ( J:84851 )

♂ • chimeric seminiferous tubules with a 3% to 100% germ cell depletion displayed smaller than average tubule diameters

small testis ( J:84851 )

♂ • at 5-8 months of age, chimeric testes were grossly reduced in size relative to wild-type testes

cellular

decreased male germ cell number ( J:84851 )

♂ • a partial to total deficiency of male germ cells was observed within some chimeric seminiferous tubules

azoospermia ( J:84851 )

♂ • a sterile chimeric mouse with 90% chimerism showed complete absence of mature sperm in the epididymis, consistent with the finding that even the few germ cells found in the remaining (30%) aberrant regions of seminiferous tubules failed to develop to term

Genotype
MGI:3621548

ht3

• Allelic Composition: Hmga1^tm1Afus/Hmga1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

cardiovascular system

cardiac hypertrophy ( J:106702 )

• no hypertension seen

• heart weight/body weight ratio increased by 35%

immune system

enlarged spleen ( J:106702 )

• in 78% of heterozygotes over 12 months of age

hematopoietic system

enlarged spleen ( J:106702 )

• in 78% of heterozygotes over 12 months of age

growth/size/body

cardiac hypertrophy ( J:106702 )

• no hypertension seen

• heart weight/body weight ratio increased by 35%

enlarged spleen ( J:106702 )

• in 78% of heterozygotes over 12 months of age

Genotype
MGI:3583952

ht4

• Allelic Composition: Hmga1^tm1Brun/Hmga1⁺
• Genetic Background: Not Specified

homeostasis/metabolism

decreased insulin secretion ( J:99652 )

• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion

decreased circulating insulin level ( J:99652 )

• plasma insulin levels but not glucose levels are significantly reduced

impaired glucose tolerance ( J:99652 )

• glucose intolerance is 71% impaired glucose tolerance and 28% diabetes

increased insulin sensitivity ( J:99652 )

• increased insulin sensitivity is seen in the skeletal muscle and fat

insulin resistance ( J:99652 )

• insulin resistance is seen in the liver as seen by increased glucose production under hyperinsulinemic conditions

endocrine/exocrine glands

decreased insulin secretion ( J:99652 )

• plasma insulin is also decreased after glucose challenge with a striking effect on acute first-phase insulin secretion

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:99652