Phenotypes associated with this allele

• Allele Symbol: Hspa5⁺
• Allele Name: wild type
• Allele ID: MGI:2430776
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hspa5^tm1Aoe/Hspa5^+	B6.129-Hspa5^tm1Aoe	MGI:3773639
ht2	Hspa5^tm1.1(KOMP)Vlcg/Hspa5^+	C57BL/6N-Hspa5^tm1.1(KOMP)Vlcg/J	MGI:5631207
cn3	Hspa5^tm1Alee/Hspa5^+ Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)4Prb/?	involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2	MGI:4943514

Genotype
MGI:3773639

ht1

• Allelic Composition: Hspa5^tm1Aoe/Hspa5⁺
• Genetic Background: B6.129-Hspa5^tm1Aoe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal interstitial fibrosis ( J:130961 )

• in aged mice

abnormal renal tubule morphology ( J:130961 )

• while young mice exhibit normal kidney morphology, aged mice exhibit tubular-interstitial lesions including tubular atrophy, tubular luminal dilation and interstitial fibrosis

renal tubule atrophy ( J:130961 )

• in aged mice

dilated renal tubule ( J:130961 )

• in aged mice

homeostasis/metabolism

increased susceptibility to injury ( J:130961 )

• despite normal appearance, induction of proteinuria by BSA-overload in young mice results in increased tubular damage, serum creatinine level and tubular cell apoptosis compared to in wild-type mice

Genotype
MGI:5631207

ht2

• Allelic Composition: Hspa5^{tm1.1(KOMP)Vlcg}/Hspa5⁺
• Genetic Background: C57BL/6N-Hspa5^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 12997A-A1

Data Sources

IMPC Data for Hspa5

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♀

IMPC - JAX

increased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - JAX

decreased circulating chloride level ( J:211773 )

♂

IMPC - JAX

Genotype
MGI:4943514

cn3

• Allelic Composition: Hspa5^tm1Alee/Hspa5⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Pbsn-cre)4Prb/?
• Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

neoplasm

increased prostate gland adenocarcinoma incidence ( J:142106 )

♂ • mutants exhibit visible solid tumor mass with invasive adenocarcinoma in the anterior prostate, while the dorsolateral prostate and ventral prostate lobes keep their ductual structure, albeit with enlarged ducts

increased prostate intraepithelial neoplasia incidence ( J:142106 )

♂ • dorsolateral prostate and ventral prostate exhibit diffusive prostate intraepithelial neoplasia (PIN) with intact basement membrane

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:142106 )

♂ • mutants exhibit visible solid tumor mass with invasive adenocarcinoma in the anterior prostate, while the dorsolateral prostate and ventral prostate lobes keep their ductual structure, albeit with enlarged ducts

increased prostate intraepithelial neoplasia incidence ( J:142106 )

♂ • dorsolateral prostate and ventral prostate exhibit diffusive prostate intraepithelial neoplasia (PIN) with intact basement membrane

reproductive system

increased prostate gland adenocarcinoma incidence ( J:142106 )

♂ • mutants exhibit visible solid tumor mass with invasive adenocarcinoma in the anterior prostate, while the dorsolateral prostate and ventral prostate lobes keep their ductual structure, albeit with enlarged ducts

increased prostate intraepithelial neoplasia incidence ( J:142106 )

♂ • dorsolateral prostate and ventral prostate exhibit diffusive prostate intraepithelial neoplasia (PIN) with intact basement membrane