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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gnaq+
wild type
MGI:2430744
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		GnaqMhdadsk10/Gnaq+ C3HeB/FeJ-GnaqDsk10 MGI:2681785
ht2
 		GnaqMhdadsk1/Gnaq+ C3HeB/FeJ-GnaqMhdadsk1/Ieg MGI:2681769
ht3
 		GnaqM1J/Gnaq+ C57BL/6J-GnaqM1J/GrsrJ MGI:5775808
cn4
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaq+
Tg(PTH-cre)4167Slib/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:3796553
cx5
 		Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaq+ 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3037555
cx6
 		Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaq+ 		involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3037554


Genotype
MGI:2681785
ht1
Allelic
Composition		 GnaqMhdadsk10/Gnaq+
Genetic
Background		 C3HeB/FeJ-GnaqDsk10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GnaqMhdadsk10 mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:81301 )
• slight darkening of the hair
• more severe in homozygous than heterozygous animals
hyperpigmentation ( J:81301 )
• excess pigmentation is first seen at P3 increases through weaning then fades with age
increased ear pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the ears
• more severe in homozygous than heterozygous animals
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
• more severe in homozygous than heterozygous animals
increased tail pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the tail
• more severe in homozygous than heterozygous animals

hearing/vestibular/ear
increased ear pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the ears
• more severe in homozygous than heterozygous animals

limbs/digits/tail
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
• more severe in homozygous than heterozygous animals
increased tail pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the tail
• more severe in homozygous than heterozygous animals

craniofacial
increased ear pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the ears
• more severe in homozygous than heterozygous animals

integument
increased ear pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the ears
• more severe in homozygous than heterozygous animals
darkened coat color ( J:81301 )
• slight darkening of the hair
• more severe in homozygous than heterozygous animals
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
• more severe in homozygous than heterozygous animals
increased tail pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the tail
• more severe in homozygous than heterozygous animals

growth/size/body
increased ear pigmentation ( J:81301 )
• extremely dark pigmentation in dermis of the ears
• more severe in homozygous than heterozygous animals




Genotype
MGI:2681769
ht2
Allelic
Composition		 GnaqMhdadsk1/Gnaq+
Genetic
Background		 C3HeB/FeJ-GnaqMhdadsk1/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GnaqMhdadsk1 mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:81301 )
• slight darkening of the hair
• more severe in homozygous than heterozygous animals
increased ear pigmentation ( J:86685 )
• black pigmentation of the ears
• more severe in homozygous than heterozygous animals
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
• more severe in homozygous than heterozygous animals
increased tail pigmentation ( J:86685 )
• black pigmentation of the tail
• more severe in homozygous than heterozygous animals

hearing/vestibular/ear
increased ear pigmentation ( J:86685 )
• black pigmentation of the ears
• more severe in homozygous than heterozygous animals

limbs/digits/tail
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
• more severe in homozygous than heterozygous animals
increased tail pigmentation ( J:86685 )
• black pigmentation of the tail
• more severe in homozygous than heterozygous animals

craniofacial
increased ear pigmentation ( J:86685 )
• black pigmentation of the ears
• more severe in homozygous than heterozygous animals

integument
darkened coat color ( J:81301 )
• slight darkening of the hair
• more severe in homozygous than heterozygous animals
increased ear pigmentation ( J:86685 )
• black pigmentation of the ears
• more severe in homozygous than heterozygous animals
increased foot pad pigmentation ( J:81301 )
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
• more severe in homozygous than heterozygous animals
increased tail pigmentation ( J:86685 )
• black pigmentation of the tail
• more severe in homozygous than heterozygous animals

growth/size/body
increased ear pigmentation ( J:86685 )
• black pigmentation of the ears
• more severe in homozygous than heterozygous animals




Genotype
MGI:5775808
ht3
Allelic
Composition		 GnaqM1J/Gnaq+
Genetic
Background		 C57BL/6J-GnaqM1J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GnaqM1J mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:231947 )
• heterozygotes have dermal and epidermal hyperpigmentation with darker than normal skin particularly in the ears, tail, lower legs, foot pats, and dorsal skin, and histology shows pigmentation in the dermal papilla extending into the underlying dermis, distinct from the phenotype caused by other allles

integument
darkened coat color ( J:231947 )
• heterozygotes have dermal and epidermal hyperpigmentation with darker than normal skin particularly in the ears, tail, lower legs, foot pats, and dorsal skin, and histology shows pigmentation in the dermal papilla extending into the underlying dermis, distinct from the phenotype caused by other allles

growth/size/body
increased ear pigmentation ( J:231947 )

craniofacial

hearing/vestibular/ear

limbs/digits/tail




Genotype
MGI:3796553
cn4
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaq+
Tg(PTH-cre)4167Slib/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(PTH-cre)4167Slib mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:116986 )
• reduced at P9 compared to controls

homeostasis/metabolism
increased circulating parathyroid hormone level ( J:116986 )
• levels are increased compared to controls
abnormal circulating calcium level ( J:116986 )
• increased relative to controls at P9
abnormal urine calcium level ( J:116986 )
• increased relative to controls

renal/urinary system
abnormal urine calcium level ( J:116986 )
• increased relative to controls




Genotype
MGI:3037555
cx5
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaq+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:49140 )
• animals die within 1-2 hours after birth

behavior/neurological
hyporesponsive to tactile stimuli ( J:49140 )
• poorly responsive to tactile stiluli

cardiovascular system
abnormal heart size ( J:49140 )
• hearts are described as malformed, either hypertrophic or hypotrophic

growth/size/body
decreased body size ( J:49140 )
• animals appear runted at birth

respiratory system
abnormal breathing pattern ( J:49140 )
• arrythmic breathing
decreased pulmonary respiratory rate ( J:49140 )
• animals breathed at approximately half the rate of controls

homeostasis/metabolism
hypoxia ( J:49140 )
• apparent at birth




Genotype
MGI:3037554
cx6
Allelic
Composition		 Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaq+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm1Soff mutation (1 available); any Gnaq mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:49140 )
• mice are viable and fertile




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory