Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gad2+ wild type MGI:2430732 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduction in aggression, shown by reduced number of attacks, is observed towards intruder male, but latencies for attack and tail rattling are unchanged, and grooming of intruder is only moderately reduced
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• a single dose of diazepam does not produce increased activity is the light compartment in a light/dark avoidance test as observed with wild-type mice; total exploratory behavior in the test is increased in wild-type mice but not in mutants
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• seizure threshold dose of phenylenetetrazol is intermediate between homozygotes and wild-type mice
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• GABA content shows a 2-month delay in increase of amygdala content, resulting in a transient reduction relative to wild-type at 2-3 months of age; significant reduction in GABA levels is detected in hypothalamus at 2 and 3 months, and in cortex at 2 months
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• seizure threshold dose of phenylenetetrazol is intermediate between homozygotes and wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an impairment in cognitive performance in the novel object recognition test
• however, mice do not show changes in sociability, social novelty, rearing, marble burying, elevated plus maze, or T-maze
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• mice exhibit elevated anxiety levels, spending less time in centers of the open field
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• mice exhibit reduced grooming behavior
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased seizure susceptibility in response 20mg/kg kainic acid as compared to controls
• decreased epilepitform activity over 120 min recording period
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• decreased average number of action potentials fired in CA1 pyramidal neurons in response to current injections above 40 pA
• decreased average number of action potentials fired in dentate gyrus granule cells in response to current injections above 60 pA
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• decrease in tonic GABAergic currents recorded in interneurons from the molecular layer of the hippocampus as compared to controls
• decrease in tonic GABAergic currents recorded in interneurons from the stratum radiatum layer of the hippocampus as compared to controls
• increase in tonic GABAergic currents recorded in CA1 pyramidal neurons, however, no difference is observed in dentate gyrus granule cells as compared to controls
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• increase in spontaneous firing rate of stratum radiatum layer interneurons as compared to controls
• increase in firing rate of stratum radiatum layer interneurons in response to a single 1 s, 100 pA current injection as compared to controls
• increase in firing rate of molecular layer interneurons in response to a single 1 s, 100 pA current injection as compared to controls
• no differences are observed in resting potential or input resistance
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• half maximal current amplitude (I50) is increased in CA1 pyramidal neurons and dentate gyrus granule cells as compared to controls
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• frequency of spontaneous IPSCs is increased in dentate gyrus granule cells (DGGCs) and CA1 pyramidal neurons
• peak amplitude of spontaneous IPSCs is increased in DGGCs and CA1 pyramidal neurons
• decrease in average inter-event interval (IEI) of spontaneous IPSCs
• increase in percentage of DGGCs and CA1 pyramidal cells following bursts of inhibitory postsynaptic currents as compared to control
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• decreased seizure susceptibility in response 20mg/kg kainic acid as compared to controls
• decreased epilepitform activity over 120 min recording period
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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