All Phenotypes Fosb<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fosb⁺
wild type
MGI:2430692

Summary

3 genotypes

Allelic Composition	Fosb^tm1.1Yun/Fosb⁺
Genetic Background	B6.129S-Fosb^tm1.1Yun

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosb^tm1.1Yun mutation (1 available); any Fosb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• open field exploratory behavior is greater than controls at day 1

• although exploratory behavior declines by day 2, it remains greater than in controls

• stayed significantly longer in the open arms of an elevated maze than do controls

abnormal locomotor activation ( J:220448 )

• significantly greater locomotor activity than controls or heterozygotes when housed alone for three days

increased locomotor activity ( J:220448 )

• greater hyperlocomotion in the active phase of the circadian cycle than seen in other genotypes

• transient hyperlocomotion induced by methylphenidate (MPH)

Allelic Composition	Fosb^tm1Meg/Fosb⁺
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosb^tm1Meg mutation (1 available); any Fosb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• mice show fewer numbers of REM sleep bouts than wild-type

Allelic Composition	Fosb^tm2.1Yun/Fosb⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosb^tm2.1Yun mutation (1 available); any Fosb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor activation ( J:220448 )

• show somewhat more locomotor activity than controls when housed alone for one month

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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