All Phenotypes Gdf1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gdf1⁺
wild type
MGI:2430589

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Acvr1c^tm1Cfi/Acvr1c⁺ Gdf1^tm1Sjl/Gdf1⁺ Nodal^tm1Rob/Nodal⁺	involves: 129 * C57BL/6	MGI:3625850
cx2	Acvr1b^tm1Enl/Acvr1b⁺ Gdf1^tm1Sjl/Gdf1⁺ Nodal^tm1Rob/Nodal⁺	involves: 129/Sv * C57BL/6	MGI:3625853
cx3	Gdf1^tm1Sjl/Gdf1⁺ Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi}	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764837
cx4	Gdf1^tm1Sjl/Gdf1⁺ Gdf3^{Gt(AD0857)Wtsi}/Gdf3⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764838

Allelic Composition	Acvr1c^tm1Cfi/Acvr1c⁺ Gdf1^tm1Sjl/Gdf1⁺ Nodal^tm1Rob/Nodal⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1c^tm1Cfi mutation (1 available); any Acvr1c mutation (38 available)
Gdf1^tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Nodal^tm1Rob mutation (2 available); any Nodal mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:108723 )

Allelic Composition	Acvr1b^tm1Enl/Acvr1b⁺ Gdf1^tm1Sjl/Gdf1⁺ Nodal^tm1Rob/Nodal⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1b^tm1Enl mutation (0 available); any Acvr1b mutation (37 available)
Gdf1^tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Nodal^tm1Rob mutation (2 available); any Nodal mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain morphology ( J:108723 )

• 3 of 19 mutants have a single forebrain vesicle

respiratory system

abnormal nasal septum morphology ( J:108723 )

• 3 of 19 mutants have a fused nasal cavity

craniofacial

abnormal nasal septum morphology ( J:108723 )

• 3 of 19 mutants have a fused nasal cavity

growth/size/body

abnormal nasal septum morphology ( J:108723 )

• 3 of 19 mutants have a fused nasal cavity

Allelic Composition	Gdf1^tm1Sjl/Gdf1⁺ Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi}
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf1^tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Gdf3^{Gt(AD0857)Wtsi} mutation (0 available); any Gdf3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:127541 )

• 50% of mice survive into adulthood

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:127541 )

• 50% of embryos die by this stage with the remaining 50% surviving into adulthood

embryo

abnormal anterior visceral endoderm cell migration ( J:127541 )

• 30% of E6.5 embryos develop AVE distally but the tissue fails to migrate to the anterior side of the pregastrulation embryo

absent mesoderm ( J:127541 )

• 18% of E7.5 embryos lack a mesoderm as determined by an absence of FoxA2 staining

abnormal primitive streak formation ( J:127541 )

• 30% of E7.5 embryos display defects in primitive streak elongation with some embryos displaying two primitive streaks

abnormal primitive streak elongation ( J:127541 )

• 30% of E7.5 embryos display defects in primitive streak elongation

absent anterior visceral endoderm ( J:127541 )

• 15% of E6.5 embryos fail to develop the anterior visceral endoderm (AVE)

cellular

abnormal anterior visceral endoderm cell migration ( J:127541 )

• 30% of E6.5 embryos develop AVE distally but the tissue fails to migrate to the anterior side of the pregastrulation embryo

Allelic Composition	Gdf1^tm1Sjl/Gdf1⁺ Gdf3^{Gt(AD0857)Wtsi}/Gdf3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:127541 )

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