All Phenotypes Gas1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gas1⁺
wild type
MGI:2430567

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Boc^tm1Aok/Boc⁺ Gas1^tm2Fan/Gas1⁺	involves: 129 * C57BL/6 * CD-1	MGI:7287690
cx2	Cdon^tm2Rsk/Cdon^tm2Rsk Gas1^tm2Fan/Gas1⁺	involves: 129 * C57BL/6J	MGI:3711888
cx3	Gas1^tm2Fan/Gas1⁺ Shh^tm1Chg/Shh⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3711885

Allelic Composition	Boc^tm1Aok/Boc⁺ Gas1^tm2Fan/Gas1⁺
Genetic Background	involves: 129 * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Boc^tm1Aok mutation (2 available); any Boc mutation (62 available)
Gas1^tm2Fan mutation (0 available); any Gas1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:310333 )

N	• mice exhibit a craniofacial midline comparable to that of wild type mice, with normal palatal development at E14.5 and normal Shh activity in the palatal shelves at E12.5

Allelic Composition	Cdon^tm2Rsk/Cdon^tm2Rsk Gas1^tm2Fan/Gas1⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdon^tm2Rsk mutation (1 available); any Cdon mutation (64 available)
Gas1^tm2Fan mutation (0 available); any Gas1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

hindlimb oligodactyly ( J:121553 )

• digit 2 or 3 is complete absent form hindlimbs

syndactyly ( J:121553 )

• forelimb digits 2 and 3 are fused

skeleton

abnormal vertebral body morphology ( J:121553 )

• lack of ossification

Allelic Composition	Gas1^tm2Fan/Gas1⁺ Shh^tm1Chg/Shh⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas1^tm2Fan mutation (0 available); any Gas1 mutation (16 available)
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuronal precursor cell number ( J:121553 )

• pMN motorneuron progenitor cell numbers are increased

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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