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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ets2+
wild type
MGI:2430484
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ets2m1Mhda/Ets2+ C3HeB/FeJ-Ets2m1Mhda MGI:5702959
cn2
 		Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/? 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:3615263
cn3
 		Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/? 		involves: 129S4/SvJaeSor * FVB/N MGI:3615265
cx4
 		Ets2tm1Rgo/Ets2+
Tg(MMTV-PyVT)634Mul/0 		involves: 129S2/SvPas * Black Swiss * FVB/N MGI:2680919


Genotype
MGI:5702959
ht1
Allelic
Composition		 Ets2m1Mhda/Ets2+
Genetic
Background		 C3HeB/FeJ-Ets2m1Mhda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2m1Mhda mutation (1 available); any Ets2 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3615263
cn2
Allelic
Composition		 Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (37 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 137 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:3615265
cn3
Allelic
Composition		 Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
Genetic
Background		 involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (37 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Tg(MMTV-cre)7Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:102368 )
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:2680919
cx4
Allelic
Composition		 Ets2tm1Rgo/Ets2+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129S2/SvPas * Black Swiss * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (37 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:57272 )
• reduced size of mammary tumors relative to controls
• correlated with a more differentiated state of early hyperplastic growths




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory