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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crh+
wild type
MGI:2430292
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Crhtm1.1(cre)Dolsn/Crh+
Mc4rtm1Lowl/Mc4rtm1Lowl 		involves: 129S4/SvJaeSor * C57BL/6 MGI:5609691
cn2
 		Crhtm1.1(cre)Dolsn/Crh+
Mc4rtm1Lowl/Mc4rtm1Lowl
Oxttm1.1(cre)Dolsn/Oxt+ 		involves: 129S4/SvJaeSor * C57BL/6 MGI:5609693
cx3
 		Crhtm1Maj/Crh+
Tg(MECP2)1Hzo/0 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5314414


Genotype
MGI:5609691
cn1
Allelic
Composition		 Crhtm1.1(cre)Dolsn/Crh+
Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhtm1.1(cre)Dolsn mutation (0 available); any Crh mutation (39 available)
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:216397 )




Genotype
MGI:5609693
cn2
Allelic
Composition		 Crhtm1.1(cre)Dolsn/Crh+
Mc4rtm1Lowl/Mc4rtm1Lowl
Oxttm1.1(cre)Dolsn/Oxt+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhtm1.1(cre)Dolsn mutation (0 available); any Crh mutation (39 available)
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (46 available)
Oxttm1.1(cre)Dolsn mutation (1 available); any Oxt mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:216397 )




Genotype
MGI:5314414
cx3
Allelic
Composition		 Crhtm1Maj/Crh+
Tg(MECP2)1Hzo/0
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhtm1Maj mutation (2 available); any Crh mutation (39 available)
Tg(MECP2)1Hzo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:181213 )
• anxiety-like behavior is reduced compared to single Tg(MECP2)1Hzo hemizygous mice, with double mutants being less anxious in the elevated plus maze and the light/dark box

homeostasis/metabolism
abnormal corticosterone level ( J:181213 )
• mutants exhibit a decrease in stress-induced serum corticosterone levels from that seen in single Tg(MECP2)1Hzo hemizygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory