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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd44+
wild type
MGI:2430266
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cd44tm1Mak/Cd44+ involves: 129P2/OlaHsd * C57BL/6J MGI:4943490
cx2
 		Apoetm1Unc/Apoetm1Unc
Cd44tm1Mak/Cd44+ 		B6.129P2-Cd44tm1Mak Apoetm1Unc MGI:4942389
cx3
 		Cd44tm1Hbg/Cd44+
Tnftm2Gkl/Tnf+ 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5702939


Genotype
MGI:4943490
ht1
Allelic
Composition		 Cd44tm1Mak/Cd44+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm1Mak mutation (1 available); any Cd44 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:99032 )
• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells
• trend towards slower migration speed
• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo
• trend towards reduced numbers of neutrophil in response to fMLP in vivo

cellular
abnormal leukocyte migration ( J:99032 )
• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells
• trend towards slower migration speed
• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo
• trend towards reduced numbers of neutrophil in response to fMLP in vivo

hematopoietic system
abnormal leukocyte migration ( J:99032 )
• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells
• trend towards slower migration speed
• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo
• trend towards reduced numbers of neutrophil in response to fMLP in vivo




Genotype
MGI:4942389
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Cd44tm1Mak/Cd44+
Genetic
Background		 B6.129P2-Cd44tm1Mak Apoetm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Cd44tm1Mak mutation (1 available); any Cd44 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:72315 )
• reduced lesion area in the thoracic abdominal aorta
• normal plasma cholesterol levels




Genotype
MGI:5702939
cx3
Allelic
Composition		 Cd44tm1Hbg/Cd44+
Tnftm2Gkl/Tnf+
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm1Hbg mutation (4 available); any Cd44 mutation (73 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
ileum inflammation ( J:145626 )
• reduced ileitis compared with Tnftm2Gkl heterozygous mice

immune system
ileum inflammation ( J:145626 )
• reduced ileitis compared with Tnftm2Gkl heterozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory