Phenotypes associated with this allele

• Allele Symbol: Col4a2⁺
• Allele Name: wild type
• Allele ID: MGI:2430164
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Col4a2^ENU415/Col4a2^+	C3.Cg-Col4a2^ENU415	MGI:4822253
ht2	Col4a2^ENU4003/Col4a2^+	C3.D2-Col4a2^ENU4003	MGI:4822255
ht3	Col4a2^ENU4020/Col4a2^+	C3.D2-Col4a2^ENU4020	MGI:4822323
ht4	Col4a2^em1(IMPC)Wtsi/Col4a2^+	C57BL/6N-Col4a2^em1(IMPC)Wtsi/WtsiOulu	MGI:7388734

Genotype
MGI:4822253

ht1

• Allelic Composition: Col4a2^ENU415/Col4a2⁺
• Genetic Background: C3.Cg-Col4a2^ENU415

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased cornea thickness ( J:163225 )

• cornea is thickened

abnormal eye anterior chamber morphology ( J:163225 )

• reduced distance separating the cornea and the lens

cataract ( J:163225 )

• examples of total lens opacity

microphthalmia ( J:163225 )

hematopoietic system

decreased erythrocyte cell number ( J:163225 )

decreased hematocrit ( J:163225 )

decreased hemoglobin content ( J:163225 )

nervous system

abnormal brain morphology ( J:163225 )

• abnormalities observed in some but not all mice

cardiovascular system

hemorrhage ( J:163225 )

Genotype
MGI:4822255

ht2

• Allelic Composition: Col4a2^ENU4003/Col4a2⁺
• Genetic Background: C3.D2-Col4a2^ENU4003

vision/eye

abnormal lens morphology ( J:163225 )

• total lens opacity

anterior polar cataract ( J:163225 )

buphthalmos ( J:163225 )

microphthalmia ( J:163225 )

hematopoietic system

decreased erythrocyte cell number ( J:163225 )

decreased hematocrit ( J:163225 )

decreased hemoglobin content ( J:163225 )

nervous system

abnormal brain morphology ( J:163225 )

• abnormal brain anatomy in some but not all mice

cardiovascular system

hemorrhage ( J:163225 )

• intraorbital hemorrhage

Genotype
MGI:4822323

ht3

• Allelic Composition: Col4a2^ENU4020/Col4a2⁺
• Genetic Background: C3.D2-Col4a2^ENU4020

vision/eye

corneal-lenticular stalk ( J:163225 )

• adhesions between the cornea and the lens

lens vacuoles ( J:163225 )

abnormal lens epithelium morphology ( J:163225 )

• disorganized

anterior polar cataract ( J:163225 )

total cataract ( J:163225 )

• total lens opacity

hematopoietic system

decreased erythrocyte cell number ( J:163225 )

decreased hematocrit ( J:163225 )

decreased hemoglobin content ( J:163225 )

nervous system

abnormal brain morphology ( J:163225 )

• brain abnormalities in some but not all mice

Genotype
MGI:7388734

ht4

• Allelic Composition: Col4a2^{em1(IMPC)Wtsi}/Col4a2⁺
• Genetic Background: C57BL/6N-Col4a2^{em1(IMPC)Wtsi}/WtsiOulu

Data Sources

IMPC Data for Col4a2

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

♂

IMPC - WTSI

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - WTSI

decreased circulating total protein level ( J:211773 )

♂

IMPC - WTSI