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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp1a1+
wild type
MGI:2430036
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Atp1a1em1(IMPC)Ccpcz/Atp1a1+ C57BL/6NCrl-Atp1a1em1(IMPC)Ccpcz/Ccpcz MGI:7414787
ht2
Atp1a1tm1Ling/Atp1a1+ involves: 129P2/OlaHsd MGI:3694084
ht3
Atp1a1tm1Ling/Atp1a1+ involves: 129P2/OlaHsd * Black Swiss MGI:3697482
ht4
Atp1a1tm1Ling/Atp1a1+ involves: 129P2/OlaHsd * C57BL/6 * Black Swiss MGI:2451294
ht5
Atp1a1Gt(OST31117)Lex/Atp1a1+ involves: 129S5/SvEvBrd * C57BL/6J MGI:3609635


Genotype
MGI:7414787
ht1
Allelic
Composition
Atp1a1em1(IMPC)Ccpcz/Atp1a1+
Genetic
Background
C57BL/6NCrl-Atp1a1em1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1em1(IMPC)Ccpcz mutation (1 available); any Atp1a1 mutation (61 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
IMPC - CCP-IMG
IMPC - CCP-IMG
IMPC - CCP-IMG

endocrine/exocrine glands
IMPC - CCP-IMG

growth/size/body
IMPC - CCP-IMG

hematopoietic system
IMPC - CCP-IMG

immune system
IMPC - CCP-IMG
IMPC - CCP-IMG

integument

limbs/digits/tail

muscle

reproductive system




Genotype
MGI:3694084
ht2
Allelic
Composition
Atp1a1tm1Ling/Atp1a1+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• peak tetanic force produced by extensor digitorum longus (EDL) muscle at supramaximal stimulation is ~240 mN/sq. mm compared to 297 mN/sq. mm in wild-type
• EDL muscle produces similar twitch force to wild-type muscle
• contractility of mutant muscle is increased with ouabain inhibition of Atp1a2
• constant for fatigue is similar to wild-type




Genotype
MGI:3697482
ht3
Allelic
Composition
Atp1a1tm1Ling/Atp1a1+
Genetic
Background
involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• increase in peak activity elicited by methamphetamine and prolonged habituation time
• increased swimming speed during hidden platform training in a Morris water maze; however, latency to find the platform is not significantly different from wild-type

homeostasis/metabolism
• increase in basal and post methamphetamine challenge serum levels
• however, levels of norepinephrine, dopamine, serotonin, and their metabolites are all similar to wild-type mice




Genotype
MGI:2451294
ht4
Allelic
Composition
Atp1a1tm1Ling/Atp1a1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hearts are hypocontractile

muscle
• hearts are hypocontractile




Genotype
MGI:3609635
ht5
Allelic
Composition
Atp1a1Gt(OST31117)Lex/Atp1a1+
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1Gt(OST31117)Lex mutation (2 available); any Atp1a1 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• during open field activity testing
• during open field activity testing





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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory