All Phenotypes Grin1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grin1⁺
wild type
MGI:2430019

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Grin1^Rgsc174/Grin1⁺	C57BL/6J-Grin1^Rgsc174	MGI:4457487
ht2	Grin1^{tm1a(EUCOMM)Wtsi}/Grin1⁺	C57BL/6N-Grin1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5781633
ht3	Grin1^Rgsc174/Grin1⁺	(D2.B6-Grin1^Rgsc174 x C57BL/6J)F1	MGI:4457489
ht4	Grin1^tm1.1Slab/Grin1⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:2655234
ht5	Grin1^tm2.1Phs/Grin1⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3586702
ht6	Grin1^tm1.1Phs/Grin1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3845916
ht7	Grin1^tm1Jjwd/Grin1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5574229
ht8	Grin1^Rgsc174/Grin1⁺	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3798979
cx9	Grin1^tm1Stl/Grin1⁺ Nf1^tm1Tyj/Nf1⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3580057

Allelic Composition	Grin1^Rgsc174/Grin1⁺
Genetic Background	C57BL/6J-Grin1^Rgsc174

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^Rgsc174 mutation (0 available); any Grin1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:160947 )

N	• mice exhibit normal anxiety in a light-dark transition test and spend the same amount of time in the center of an open field as wild-type mice

abnormal behavioral response to xenobiotic ( J:160947 )

• D,l-methylphenidate hydrochloride (MPH)-treated mice exhibit reduced locomotor activity unlike similarly treated wild-type mice

increased exploration in new environment ( J:160947 )

• mice exhibit increased exploration of a tube filled with marbles compared with wild-type mice

• however, time spent exploring the object is normal

hyperactivity ( J:160947 )

• mice exhibit increased activity in an open field test and home cage during the dark period compared with wild-type mice

• however, mice exhibit normal rest-activity cycles under standard light-dark cycle

abnormal social investigation ( J:160947 )

• mice exhibit reduced exploration interacting with other mice compared with wild-type mice

nervous system

abnormal neuron physiology ( J:160947 )

• more c-Fos immunoreactive cells are found in the prelimbic cortex than in wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:160947 )

• D,l-methylphenidate hydrochloride (MPH)-treated mice exhibit a lesser increase in c-Fos immunoreactive cells in the dorsal striatum than similarly treated wild-type mice

• MPH-treated mice exhibit a decrease in c-Fos immunoreactive cells in the prelimbic cortex compared with similarly treated wild-type mice

Allelic Composition	Grin1^{tm1a(EUCOMM)Wtsi}/Grin1⁺
Genetic Background	C57BL/6N-Grin1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0469_5_C11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^{tm1a(EUCOMM)Wtsi} mutation (3 available); any Grin1 mutation (64 available)

Data Sources

IMPC Data for Grin1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytopenia ( J:175295 )

IMPC - WTSI

Allelic Composition	Grin1^Rgsc174/Grin1⁺
Genetic Background	(D2.B6-Grin1^Rgsc174 x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^Rgsc174 mutation (0 available); any Grin1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:160947 )

N	• mice exhibit normal response in a resident-intruder test

Allelic Composition	Grin1^tm1.1Slab/Grin1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1.1Slab mutation (0 available); any Grin1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:82670 )

• mice died within 6 hours of birth

• no milk uptake even after the removal of wild-type pups

behavior/neurological

hyperactivity ( J:82670 )

respiratory system

respiratory distress ( J:82670 )

Allelic Composition	Grin1^tm2.1Phs/Grin1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm2.1Phs mutation (0 available); any Grin1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:75497 )

• death within 4 weeks of birth

• 2/3 die with in the first 2 days after birth

behavior/neurological

abnormal food intake ( J:75497 )

• poor feeding

abnormal motor capabilities/coordination/movement ( J:75497 )

impaired righting response ( J:75497 )

decreased locomotor activity ( J:75497 )

growth/size/body

postnatal growth retardation ( J:75497 )

Allelic Composition	Grin1^tm1.1Phs/Grin1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1.1Phs mutation (0 available); any Grin1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75497 )

• higher than normal mortality over the first year of life

behavior/neurological

hyperactivity ( J:75497 )

• pregnant females become hyperactive before delivery

abnormal social/conspecific interaction behavior ( J:75497 )

abnormal maternal nurturing ( J:75497 )

• litters are typically underfed and die or are killed within 2 days

abnormal maternal grooming ( J:75497 )

• mothers fail to clean pups

absent maternal crouching ( J:75497 )

• mothers fail to crouch over newborn pups

abnormal pup retrieval ( J:75497 )

• mothers fail to retrieve pups

pup cannibalization ( J:75497 )

• mothers turn aggressive toward the newborn

• newborn pups display bruises and bites and are sometimes cannibalized

abnormal nest building behavior ( J:75497 )

• after delivery, mothers perform poorly on nest building task

Allelic Composition	Grin1^tm1Jjwd/Grin1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1Jjwd mutation (0 available); any Grin1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased alcohol consumption ( J:209690 )

• during daily limited-access

increased alcohol consumption ( J:209690 )

• when given intermittent 24 hour access to ethanol

abnormal behavioral response to alcohol ( J:209690 )

• ethanol inhibition of NMDA current is intermediately impaired compared to in wild-type mice and homozygotes

• ethanol-treated mice fail to exhibit an increase in activity at low doses and exhibit less of a reduction in activity at high doses compared with wild-type mice

• ethanol-treated mice exhibit a faster recovery as tested by rotarod performance compared with wild-type mice

• ethanol-treated mice fail to exhibit an increase in time spent in the open arms of an elevated plus maze unlike wild-type mice

• however, ethanol-treated mice exhibit normal impairment of motor coordination, loss of righting reflex, hypothermia and ethanol metabolism

abnormal conditioned taste aversion behavior ( J:209690 )

• altered conditioned taste aversion to a low dose of ethanol

• however, response at higher doses is normal

abnormal anxiety-related response ( J:209690 )

• ethanol-treated mice fail to exhibit an increase in time spent in the open arms of an elevated plus maze unlike wild-type mice

• however, anxiety-related behavior is normal in saline-treated mice

nervous system

abnormal NMDA-mediated synaptic currents ( J:209690 )

• ethanol inhibition of NMDA current is intermediately impaired compared to in wild-type mice and homozygotes

• however, NMDA evoked currents are normal

taste/olfaction

taste/olfaction phenotype ( J:209690 )

N	• mice exhibit normal saccharin preference

Allelic Composition	Grin1^Rgsc174/Grin1⁺
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^Rgsc174 mutation (0 available); any Grin1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired passive avoidance behavior ( J:133634 )

• mice with this mutation exhibit a deficit of the passive avoidance response

hyperactivity ( J:133634 )

• mice heterozygous for this mutation exhibit hyperactivity in the home cage

• heterozygous mutants exhibit hyperactivity in the open field

Allelic Composition	Grin1^tm1Stl/Grin1⁺ Nf1^tm1Tyj/Nf1⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1Stl mutation (0 available); any Grin1 mutation (64 available)
Nf1^tm1Tyj mutation (3 available); any Nf1 mutation (161 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:38703 )

• spatial learning impairment in Morris Water Maze Test, however normal long term memory in cued fear conditioning test and normal nociception

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neurofibromatosis 1		DOID:0111253	OMIM:162200	J:38703

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