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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Htr2c+
wild type
MGI:2430013
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Htr2ctm1Knk/Htr2c+ B6.Cg-Htr2ctm1Knk MGI:3823076
ht2
 		Htr2cem1Yonxu/Htr2c+ C57BL/6J-Htr2cem1Yonxu MGI:8278527
ht3
 		Htr2ctm1.1Eme/Htr2c+ involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:4830463


Genotype
MGI:3823076
ht1
Allelic
Composition		 Htr2ctm1Knk/Htr2c+
Genetic
Background		 B6.Cg-Htr2ctm1Knk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1Knk mutation (1 available); any Htr2c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
slow postnatal weight gain ( J:142503 )




Genotype
MGI:8278527
ht2
Allelic
Composition		 Htr2cem1Yonxu/Htr2c+
Genetic
Background		 C57BL/6J-Htr2cem1Yonxu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2cem1Yonxu mutation (0 available); any Htr2c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:376997 )
N
• normal swimming speed in radial arm water maze test
• normal behavior in response to contextual and cued conditioning
• normal pain threshold in hot plate test
abnormal short-term spatial reference memory ( J:376997 )
• increased latency in finding the platform in radial arm water maze test 30 min. after training session




Genotype
MGI:4830463
ht3
Allelic
Composition		 Htr2ctm1.1Eme/Htr2c+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1.1Eme mutation (0 available); any Htr2c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:163043 )
• not as severe as in homozygotes or hemizygotes
postnatal growth retardation ( J:163043 )
• not as severe as in homozygotes or hemizygotes

behavior/neurological
decreased food intake ( J:163043 )
• gastric milk content is decreased compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory