All Phenotypes Stxbp5l<T2dm1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stxbp5l^T2dm1
type 2 diabetes mellitus 1
MGI:2429600

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lep^ob/Lep^ob Stxbp5l^T2dm1/Stxbp5l^T2dm1	B6.Cg-Lep^ob Chr 16^BTNTTF	MGI:5297580
cx2	Lep^ob/Lep^ob Stxbp5l^T2dm1/Stxbp5l^T2dm1 T2dm2^C57BL/6J/T2dm2^C57BL/6J	involves: BTBR * C57BL/6J	MGI:3028549

Allelic Composition	Lep^ob/Lep^ob Stxbp5l^T2dm1/Stxbp5l^T2dm1
Genetic Background	B6.Cg-Lep^ob Chr 16^BTNTTF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (19 available)
Stxbp5l^T2dm1 mutation (0 available); any Stxbp5l mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:178002 )

• mice exhibit increased fasting serum glucose compared with Lep^ob homozygotes

decreased circulating insulin level ( J:178002 )

• mice exhibit decreased fasting serum insulin compared with Lep^ob homozygotes

Allelic Composition	Lep^ob/Lep^ob Stxbp5l^T2dm1/Stxbp5l^T2dm1 T2dm2^C57BL/6J/T2dm2^C57BL/6J
Genetic Background	involves: BTBR * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:65486 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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