Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-TGFBR2)7Hlm
• Allele Name: transgene insertion 7, Harold L Moses
• Allele ID: MGI:2429406
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(MMTV-TGFBR2)7Hlm/? Tg(MMTVTGFA)29Rjc/?	involves: C57BL/6 * DBA	MGI:3794994
tg2	Tg(MMTV-TGFBR2)7Hlm/Tg(MMTV-TGFBR2)7Hlm	involves: C57BL/6 * DBA	MGI:3794972
tg3	Tg(MMTV-TGFBR2)7Hlm/0	involves: C57BL/6 * DBA	MGI:3794971

Genotype
MGI:3794994

cx1

• Allelic Composition: Tg(MMTV-TGFBR2)7Hlm/?; Tg(MMTVTGFA)29Rjc/?
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:85799 )

• 17 of 19 mice develop mammary tumors with 5 mice having tumors with invasive characteristics

• the number of invasive tumors is significantly less than mice carrying just the Tg(MMTVTGFA)29Rjc transgene

• 15 of the 17 mice with tumors had tumors in multiple mammary glands

• tumor development occurs with a median latency of 9 months

integument

increased mammary adenocarcinoma incidence ( J:85799 )

• 17 of 19 mice develop mammary tumors with 5 mice having tumors with invasive characteristics

• the number of invasive tumors is significantly less than mice carrying just the Tg(MMTVTGFA)29Rjc transgene

• 15 of the 17 mice with tumors had tumors in multiple mammary glands

• tumor development occurs with a median latency of 9 months

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:85799 )

• 17 of 19 mice develop mammary tumors with 5 mice having tumors with invasive characteristics

• the number of invasive tumors is significantly less than mice carrying just the Tg(MMTVTGFA)29Rjc transgene

• 15 of the 17 mice with tumors had tumors in multiple mammary glands

• tumor development occurs with a median latency of 9 months

Genotype
MGI:3794972

tg2

• Allelic Composition: Tg(MMTV-TGFBR2)7Hlm/Tg(MMTV-TGFBR2)7Hlm
• Genetic Background: involves: C57BL/6 * DBA

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:85799 )

♀ • there is consistent retardation of involution observed in mice both 7 and 10 days after weaning compared to control mice

abnormal mammary gland growth during lactation ( J:85799 )

♀ • there is accelerated development and differentiation of mammary epithelial cells during early to mid-pregnancy but impaired development during the last stages of pregnancy

mammary gland alveolar hyperplasia ( J:46432 , J:85799 )

♀ • alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice (J:46432)

♀ • the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland (J:46432)

♀ • the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation (J:46432)

♀ • the hyperplasia observed is more severe than observed in mice hemizyguos for the transgene (J:46432)

♀ • mice 15 days into their first pregnancy have more prominent vacuoles in the alveoli than in control mice (J:85799)

♀ • the alveolar are also in a more differentiated state as indicated by the presence of milk proteins in the lumen (J:85799)

increased mammary adenocarcinoma incidence ( J:85799 )

• mice that have experienced two rounds of pregnancy have a frequency of spontaneous mammary carcinoma

• 47% of these females develop mammary tumors with a median latency of 27.5 months

• 72% of these tumors are high grade mammary intraepithelial neoplasias

• the remaining 28% are invasive adenocarcinomas or adenosquamous carcinomas

mammary gland hypoplasia ( J:85799 )

♀ • mice have fewer alveoli 1 day after the onset of lactation than do control mice

abnormal lactation ( J:46432 )

♀ • the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females

♀ • the concentration and location of the beta-Casein is similar to what is found in 12.5-day pregnant females

hypolactation ( J:85799 )

♀ • mice are frequently unable to feed their pups

♀ • while alveolar hyperplasia with some milk production occurs early in pregnancy (15 days), the mammary glands fail to develop into fully functional organs as indicated by less extensive alveolar development and decreased milk production compared to non-transgenic controls

neoplasm

increased mammary adenocarcinoma incidence ( J:85799 )

• mice that have experienced two rounds of pregnancy have a frequency of spontaneous mammary carcinoma

• 47% of these females develop mammary tumors with a median latency of 27.5 months

• 72% of these tumors are high grade mammary intraepithelial neoplasias

• the remaining 28% are invasive adenocarcinomas or adenosquamous carcinomas

integument

abnormal involution of the mammary gland ( J:85799 )

♀ • there is consistent retardation of involution observed in mice both 7 and 10 days after weaning compared to control mice

abnormal mammary gland growth during lactation ( J:85799 )

♀ • there is accelerated development and differentiation of mammary epithelial cells during early to mid-pregnancy but impaired development during the last stages of pregnancy

mammary gland alveolar hyperplasia ( J:46432 , J:85799 )

♀ • alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice (J:46432)

♀ • the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland (J:46432)

♀ • the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation (J:46432)

♀ • the hyperplasia observed is more severe than observed in mice hemizyguos for the transgene (J:46432)

♀ • mice 15 days into their first pregnancy have more prominent vacuoles in the alveoli than in control mice (J:85799)

♀ • the alveolar are also in a more differentiated state as indicated by the presence of milk proteins in the lumen (J:85799)

increased mammary adenocarcinoma incidence ( J:85799 )

• mice that have experienced two rounds of pregnancy have a frequency of spontaneous mammary carcinoma

• 47% of these females develop mammary tumors with a median latency of 27.5 months

• 72% of these tumors are high grade mammary intraepithelial neoplasias

• the remaining 28% are invasive adenocarcinomas or adenosquamous carcinomas

mammary gland hypoplasia ( J:85799 )

♀ • mice have fewer alveoli 1 day after the onset of lactation than do control mice

abnormal lactation ( J:46432 )

♀ • the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females

♀ • the concentration and location of the beta-Casein is similar to what is found in 12.5-day pregnant females

hypolactation ( J:85799 )

♀ • mice are frequently unable to feed their pups

♀ • while alveolar hyperplasia with some milk production occurs early in pregnancy (15 days), the mammary glands fail to develop into fully functional organs as indicated by less extensive alveolar development and decreased milk production compared to non-transgenic controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:85799

Genotype
MGI:3794971

tg3

• Allelic Composition: Tg(MMTV-TGFBR2)7Hlm/0
• Genetic Background: involves: C57BL/6 * DBA

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:46432 )

♀ • alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice

♀ • the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland

♀ • the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation

♀ • the hyperplasia observed is less severe than observed in mice homozygous for the transgene

abnormal lactation ( J:46432 )

♀ • the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females

integument

mammary gland alveolar hyperplasia ( J:46432 )

♀ • alveolar hyperplasia is evident in non-pregnant females while no alveolar structures are observed in non-pregnant wild-type mice

♀ • the alveolar-like buds fill in the spaces between the ductal structure of the mammary gland

♀ • the morphology of the mammary gland resembles the morphology found in pregnant wild-type mice at early to mid-gestation

♀ • the hyperplasia observed is less severe than observed in mice homozygous for the transgene

abnormal lactation ( J:46432 )

♀ • the milk protein beta-Casein is detectable in the alveolar buds of non-pregnant females