Phenotypes associated with this allele

• Allele Symbol: Camk2a^tm1Mllr
• Allele Name: targeted mutation 1, Stephan Miller
• Allele ID: MGI:2389309
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2a^tm1Mllr/Camk2a^tm1Mllr	B6.129-Camk2a^tm1Mllr	MGI:3764502
hm2	Camk2a^tm1Mllr/Camk2a^tm1Mllr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764501

Genotype
MGI:3764502

hm1

• Allelic Composition: Camk2a^tm1Mllr/Camk2a^tm1Mllr
• Genetic Background: B6.129-Camk2a^tm1Mllr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:79713 )

• mice freeze less after 24 hours of training than wild-type mice even after additional training

• Background Sensitivity: impaired contextual conditioning is more severe than in mice on a less homogeneous background

abnormal cued conditioning behavior ( J:79713 )

• mice freeze less after 24 hours of training than wild-type mice even after additional training

• Background Sensitivity: impaired cued conditioning is more severe than in mice on a less homogeneous background

impaired long-term object recognition memory ( J:79713 )

• unlike wild-type mice, mice fail to demonstrate object recognition after 24 hours

• however, object recognition after 1 hour is normal

abnormal spatial learning ( J:79713 )

• spatial learning tested in a hidden platform Morris water maze test is impaired even after additional training

• however, motor coordination, swimming, motivation to escape the water and visual acuity are normal

Genotype
MGI:3764501

hm2

• Allelic Composition: Camk2a^tm1Mllr/Camk2a^tm1Mllr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

abnormal contextual conditioning behavior ( J:79713 )

• mice freeze less after 24 hours of training than wild-type mice

• Background Sensitivity: impaired contextual conditioning is less severe than in mice on a more homogeneous background

• however, performance can be improved with additional training

abnormal cued conditioning behavior ( J:79713 )

• mice freeze less after 24 hours of training than wild-type mice

• Background Sensitivity: impaired cued conditioning is less severe than in mice on a more homogeneous background

• however, performance can be improved with additional training

abnormal spatial learning ( J:79713 )

• spatial learning tested in a hidden platform Morris water maze test is impaired

• however, motor coordination, swimming, motivation to escape the water and visual acuity are normal and performance improves after additional training

nervous system

abnormal long-term potentiation ( J:79713 )

• 4 100 Hz bursts for 1 second each resulted in a potentiation that diverged from that of the wild-type mice by 2.5 hours (67+/-15% compared to 107+/-15% in wild-type mice)