Camk2a^tm1Mllr
Targeted Allele Detail

Summary

• Symbol: Camk2a^tm1Mllr
• Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, Stephan Miller
• MGI ID: MGI:2389309
• Gene: Camk2a Location: Chr18:61058704-61121224 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Camk2a^tm1Mllr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79713
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous 3' UTR was replaced with a bovine growth hormone 3' UTR. The bovine sequence contains an identical polyadenylation hexanucleotide but lacks a dendritic localization signal. In situ hybridization of mutant brain sections indicated that dendritic localization was disrupted. Quantification of the hybridization results showed reduced expression levels in hippocampal cell bodies (approximately 85.3% of wild-type). (J:79713)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2a Mutation: 136 strains or lines available

References

• Original: J:79713 Miller S, et al., Disruption of Dendritic Translation of CaMKIIalpha Impairs Stabilization of Synaptic Plasticity and Memory Consolidation. Neuron. 2002 Oct 24;36(3):507-19
• All: 2 reference(s)