Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm5Sva mutation
(0 available);
any
Camk2a mutation
(136 available)
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nervous system
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N |
• unlike in Camk2atm2Sva homozygotes, field excitatory postsynaptic potential, synaptic plasticity, and docked synaptic vesicle size and number are normal
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• long term potentiation is absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm5Sva mutation
(0 available);
any
Camk2a mutation
(136 available)
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behavior/neurological
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• contextual conditioning is severely disrupted
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• mice display severely impaired spatial learning in a hidden platform Morris water maze test
• in a hidden platform Morris water maze test, mice do no selectively search for the platform in the target quadrant
• however, performance was improved by additional training days
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• only 1 in 52 mice display seizures
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nervous system
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• only 1 in 52 mice display seizures
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• 2 theta burst tetanus or a strong theta burst (100 Hz for 1 second) fails to induce long term potentiation as in wild-type mice
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• long term depression is enhanced compared to in wild-type mice when stimulated with 10 Hz for 10 seconds
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Allelic
Composition |
Camk2atm5Sva/Camk2a+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm5Sva mutation
(0 available);
any
Camk2a mutation
(136 available)
|
|
|
nervous system
|
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• a strong theta burst (100 Hz for 1 second) induces a 3-fold weaker long term potentiation than in wild-type mice
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behavior/neurological
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N |
• mice exhibit normal spatial learning and contextual and cued conditioning
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Analysis Tools