Phenotypes associated with this allele

• Allele Symbol: Camk2a^tm5Sva
• Allele Name: targeted mutation 5, Alcino Silva
• Allele ID: MGI:2389272
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2a^tm5Sva/Camk2a^tm5Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764494
hm2	Camk2a^tm5Sva/Camk2a^tm5Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:3764499
ht3	Camk2a^tm5Sva/Camk2a^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:3764500

Genotype
MGI:3764494

hm1

• Allelic Composition: Camk2a^tm5Sva/Camk2a^tm5Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:127397 )

N • unlike in Camk2a^tm2Sva homozygotes, field excitatory postsynaptic potential, synaptic plasticity, and docked synaptic vesicle size and number are normal

reduced long-term potentiation ( J:127397 )

• long term potentiation is absent

Genotype
MGI:3764499

hm2

• Allelic Composition: Camk2a^tm5Sva/Camk2a^tm5Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

behavior/neurological

abnormal contextual conditioning behavior ( J:79714 )

• contextual conditioning is severely disrupted

abnormal spatial learning ( J:79714 )

• mice display severely impaired spatial learning in a hidden platform Morris water maze test

• in a hidden platform Morris water maze test, mice do no selectively search for the platform in the target quadrant

• however, performance was improved by additional training days

seizures ( J:79714 )

• only 1 in 52 mice display seizures

nervous system

seizures ( J:79714 )

• only 1 in 52 mice display seizures

reduced long-term potentiation ( J:79714 )

• 2 theta burst tetanus or a strong theta burst (100 Hz for 1 second) fails to induce long term potentiation as in wild-type mice

abnormal long-term depression ( J:79714 )

• long term depression is enhanced compared to in wild-type mice when stimulated with 10 Hz for 10 seconds

Genotype
MGI:3764500

ht3

• Allelic Composition: Camk2a^tm5Sva/Camk2a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

nervous system

reduced long-term potentiation ( J:79714 )

• a strong theta burst (100 Hz for 1 second) induces a 3-fold weaker long term potentiation than in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:79714 )

N • mice exhibit normal spatial learning and contextual and cued conditioning