All Phenotypes Hoxd11<tm2.1(Hoxd11)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxd11^{tm2.1(Hoxd11)Mrc}
targeted mutation 2.1, Mario R Capecchi
MGI:2389127

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: BALB/cJ	MGI:3810832
ht2	Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺	involves: BALB/cJ	MGI:3810833
ht3	Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: BALB/cJ	MGI:3810834
cx4	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: 129S7/SvEvBrd * BALB/cJ	MGI:3810836
cx5	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺	involves: BALB/cJ	MGI:3810830
cx6	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: BALB/cJ	MGI:3810831
cx7	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: BALB/cJ	MGI:3810839

Allelic Composition	Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd11^{tm2.1(Hoxd11)Mrc} mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal phalanx morphology ( J:78766 )

• the length of the phalanges 1 and 2 of digit II relative to the length of the humerus is increased compared to in wild-type mice

elongated metacarpal bones ( J:78766 )

• the length of digits II, III and IV relative to the length of the humerus is increased compared to in wild-type mice

decreased lumbar vertebrae number ( J:78766 )

• 5 instead of 6

limbs/digits/tail

abnormal phalanx morphology ( J:78766 )

• the length of the phalanges 1 and 2 of digit II relative to the length of the humerus is increased compared to in wild-type mice

elongated metacarpal bones ( J:78766 )

• the length of digits II, III and IV relative to the length of the humerus is increased compared to in wild-type mice

Allelic Composition	Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd11^{tm2.1(Hoxd11)Mrc} mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased lumbar vertebrae number ( J:78766 )

• 5 instead of 6

Allelic Composition	Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)
Hoxd11^{tm2.1(Hoxd11)Mrc} mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: 129S7/SvEvBrd * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)
Hoxd11^{tm2.1(Hoxd11)Mrc} mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

fused carpal bones ( J:78766 )

• the proximal carpal bones and navicular lunate are fused in four of five mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

limbs/digits/tail

fused carpal bones ( J:78766 )

• the proximal carpal bones and navicular lunate are fused in four of five mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11^{tm2.1(Hoxd11)Mrc} mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:78766 )

reduced male fertility ( J:78766 )

• 4 of 10 mice are fertile

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

limbs/digits/tail

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: BALB/cJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:78766 )

male infertility ( J:78766 )

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

limbs/digits/tail

limbs/digits/tail phenotype ( J:78766 )

N	• forearm bones are normal

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: BALB/cJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

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