Phenotypes associated with this allele

• Allele Symbol: Mllt3^tm1Thr
• Allele Name: targeted mutation 1, Terence H Rabbitts
• Allele ID: MGI:2388981
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mllt3^tm1Thr/Mllt3^tm1Thr	involves: 129S/SvEv * C57BL/6	MGI:3833416

Genotype
MGI:3833416

hm1

• Allelic Composition: Mllt3^tm1Thr/Mllt3^tm1Thr
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:79367 )

• about half are found dead at birth or die within a few hours of birth

perinatal lethality, incomplete penetrance ( J:79367 )

• about half are found dead at birth or die within a few hours of birth

postnatal lethality, complete penetrance ( J:79367 )

• no mice survive to weaning

growth/size/body

decreased body size ( J:79367 )

• mice that survive past bthe perinatal period become severely runted by 2 weeks of age

skeleton

asymmetric sternocostal joints ( J:79367 )

abnormal sternum ossification ( J:79367 )

• in newborns, sternums consist mainly of bone rather than bone and cartilage

abnormal cervical rib ( J:79367 )

• C8 has rib anlagen that does not attach to the sternum or to the first pair of thoracic ribs

decreased rib number ( J:79367 )

• lack a pair of floating ribs

abnormal vertebral column morphology ( J:79367 )

• in the region of C3 to C8 the spinal column is compressed causing an S shaped deformation of the neck and forward tilt of the head

decreased thoracic vertebrae number ( J:79367 )

• most mice are missing a vertebra, associated with loss of a pair of floating ribs

abnormal spine curvature ( J:79367 )

• S shaped deformation of the neck and forward tilt of the head

abnormal cervical vertebrae morphology ( J:79367 )

• C3 looks more like C2 than C4 with a round rather than oval cross sectional shape

abnormal cervical atlas morphology ( J:79367 )

• in all cases C1 is about twice as tall as in wild-type controls

• C1 has the appearance of 2 partially fused vertebrae

abnormal cervical axis morphology ( J:79367 )

• malformations of C2 are sometimes seen

• in a few cases C2 looks like 2 partially fused vertebrae

cervical vertebral fusion ( J:79367 )

• in some cases C2 and C3 appear partially fused

vertebral transformation ( J:79367 )

• anterior homeotic transformation from C3 through T13

• however, lumbar and caudal vertebrae appear similar to controls

thoracic vertebral transformation ( J:79367 )

• most mice have an extra cervical vertebra compensating for loss of a thoracic vertebra

• the spinous process usually found of T2 is seen on T3

embryo

abnormal developmental patterning ( J:79367 )

• in situ hybridization analysis of E9.5 mutant embryos revealed a posterior shift in the anterior expression limits of Hoxd4, corresponding to approximately one rhombomere, indicating altered embryo patterning

hematopoietic system

hematopoietic system phenotype ( J:79367 )

N • mutant neonates displayed normal hematopoiesis, as shown by histology and flow cytometry