About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sirpatm1Nog
targeted mutation 1, Tetsuya Noguchi
MGI:2388979
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sirpatm1Nog/Sirpatm1Nog B6N.129P2-Sirpatm1Nog MGI:4939903
hm2
 		Sirpatm1Nog/Sirpatm1Nog involves: 129P2/OlaHsd * C57BL/6 MGI:3056133


Genotype
MGI:4939903
hm1
Allelic
Composition		 Sirpatm1Nog/Sirpatm1Nog
Genetic
Background		 B6N.129P2-Sirpatm1Nog
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirpatm1Nog mutation (2 available); any Sirpa mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavioral despair ( J:162849 )
• increased immobility times in forced swimming tests
• active behavior becomes further suppressed in subsequent trials
• no abnormalities in other behavior tests including tail suspension tests




Genotype
MGI:3056133
hm2
Allelic
Composition		 Sirpatm1Nog/Sirpatm1Nog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirpatm1Nog mutation (2 available); any Sirpa mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Presence of megakaryocytes in the spleen of 11 week old Sirpatm1Nog/Sirpatm1Nog mice

growth/size/body
decreased body weight ( J:79592 )
• mean body mass is reduced by about 10% compared to wild-type

hematopoietic system
increased megakaryocyte cell number ( J:79592 )
• an increased number of megakaryocytes are seen in the spleen at 11 weeks of age
thrombocytopenia ( J:79592 )
• the circulating platelet count is reduced by about 25% compared to wild-type mice
• the life span of platelets is significantly decreased in mutants
decreased T cell number ( J:79592 )
• the proportion of CD4+ and CD8+ cells are decreased compared to wild-type mice
abnormal macrophage physiology ( J:79592 )
• the phagocytic activity of peritoneal macrophages is significantly enhanced

immune system
decreased T cell number ( J:79592 )
• the proportion of CD4+ and CD8+ cells are decreased compared to wild-type mice
abnormal macrophage physiology ( J:79592 )
• the phagocytic activity of peritoneal macrophages is significantly enhanced
abnormal Langerhans cell physiology ( J:88694 )
• 2,4-dinitro-1-fluorobenzene-induced migration of Langerhans cells out of the epidermis is significantly impaired

liver/biliary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory