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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Art2btm1Fkn
targeted mutation 1, Friedrich Koch-Nolte
MGI:2388827
Summary 2 genotypes


Genotype
MGI:3623961
cx1
Allelic
Composition		 Art2atm1Fkn/Art2atm1Fkn
Art2btm1Fkn/Art2btm1Fkn
Cd38tm1Lnd/Cd38tm1Lnd
Genetic
Background		 NOD.129(B6)-Cd38tm1Lnd Art2atm1Fkn Art2btm1Fkn/Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Art2atm1Fkn mutation (2 available); any Art2a mutation (9 available)
Art2btm1Fkn mutation (3 available); any Art2b mutation (23 available)
Cd38tm1Lnd mutation (4 available); any Cd38 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:108097 )
• double knockout NOD mice exhibit strong protection from diabetes in both sexes; female knockouts acquire diabetes at a frequency of 25% by 28 weeks compared to 100% in Cd38-null NOD females; double knockout NOD males are completely protected at 28 weeks compared to 100% incidence in Cd38-null NOD males




Genotype
MGI:3580315
cx2
Allelic
Composition		 Art2atm1Fkn/Art2atm1Fkn
Art2btm1Fkn/Art2btm1Fkn
Genetic
Background		 NOD.129S4(B6)-Art2atm1Fkn Art2btm1Fkn/Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Art2atm1Fkn mutation (2 available); any Art2a mutation (9 available)
Art2btm1Fkn mutation (3 available); any Art2b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:108097 )
• CD4+ and CD8+ T cells are completely resistant to NAD-mediated apoptosis in Art2-deficient NOD mice compared to wild-type NOD mice which exhibit T cell apoptosis in a dose-dependent manner compared to Art2-intact NOD mice

cellular
decreased T cell apoptosis ( J:108097 )
• CD4+ and CD8+ T cells are completely resistant to NAD-mediated apoptosis in Art2-deficient NOD mice compared to wild-type NOD mice which exhibit T cell apoptosis in a dose-dependent manner compared to Art2-intact NOD mice

hematopoietic system
decreased T cell apoptosis ( J:108097 )
• CD4+ and CD8+ T cells are completely resistant to NAD-mediated apoptosis in Art2-deficient NOD mice compared to wild-type NOD mice which exhibit T cell apoptosis in a dose-dependent manner compared to Art2-intact NOD mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory