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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lattm1.1Lov
targeted mutation 1.1, Paul E Love
MGI:2388631
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lattm1.1Lov/Lattm1.1Lov involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2446424
cx2
 		Lattm1.1Lov/Lattm1.1Lov
Lat2tm1Wz/Lat2tm1Wz 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3695389


Genotype
MGI:2446424
hm1
Allelic
Composition		 Lattm1.1Lov/Lattm1.1Lov
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Lov mutation (0 available); any Lat mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:77099 )
• most die before 6 months of age

immune system
decreased thymocyte number ( J:77099 )
• reduced to about 5 - 10% of wild-type cell number at 2 weeks of age
abnormal double-negative T cell morphology ( J:77099 )
• increase in the percentage but not total number of double negative cell in the thymus at 2 weeks of age
decreased double-positive T cell number ( J:77099 )
• reduced percentage and number in the thymus and spleen at 2 weeks of age
increased activated T cell number ( J:77099 )
• most of the CD4+ T cells appear to be activated
• mice contain a higher percentage of proliferating T cells and these cells appear to be resistant to TCR-mediated cell death
abnormal CD4-positive, alpha beta T cell morphology ( J:77099 , J:116157 )
• reduced percentage and number in the thymus and spleen at 2 weeks of age (J:77099)
• increased numbers found in the thymus, spleen and other organs by 4 weeks of age (J:77099)
• about 44% of splenocytes are CD4+ cells (J:116157)
abnormal CD8-positive, alpha beta T cell morphology ( J:77099 )
• reduced percentage and number in the thymus and spleen at 2 weeks of age
increased IgG1 level ( J:77099 )
• increase in IgG1
decreased T cell proliferation ( J:77099 )
• proliferate poorly in response to anti-CD3 stimulation but proliferation in response to phorbol myristate acetate and ionomycin or anti-CD3 and anti-CD28 is similar to wild-type
increased T cell proliferation ( J:77099 )
• T cells proliferate in response to ionomycin alone and in response to IL-2 alone unlike wild-type cells
small thymus ( J:77099 )
• at 2 weeks of age
• in older mice thymi are very small and contain a high of CD4+ T cells and B cells
enlarged spleen ( J:77099 , J:116157 )
• at 4 weeks of age (J:77099)
• contains primarily CD4+ T cells and elevated numbers of B cells, macrophages, and eosinophils (J:77099)
• enlarged at 11 weeks of age (J:116157)
spleen hyperplasia ( J:116157 )
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
enlarged lymph nodes ( J:77099 , J:116157 )
• at 4 weeks of age (J:77099)
• contains primarily CD4+ T cells and elevated numbers of B cells, macrophages, and eosinophils (J:77099)
• enlarged at 11 weeks of age (J:116157)
abnormal cytokine secretion ( J:77099 )
• T cells produce very low levels of cytokines when stimulated with anti-CD3 and anti-CD28 antibodies, but when stimulated with PMA and ionomycin produce more IL-4 compared to wild-type mice
increased autoantibody level ( J:77099 )
• increased levels of DNA autoantibodies
increased anti-nuclear antigen antibody level ( J:77099 )
• increased levels nuclear antigen autoantibodies
increased anti-double stranded DNA antibody level ( J:116157 )
• high titers of dsDNA antibodies are present at 10 weeks of age

hematopoietic system
small thymus ( J:77099 )
• at 2 weeks of age
• in older mice thymi are very small and contain a high of CD4+ T cells and B cells
decreased thymocyte number ( J:77099 )
• reduced to about 5 - 10% of wild-type cell number at 2 weeks of age
enlarged spleen ( J:77099 , J:116157 )
• at 4 weeks of age (J:77099)
• contains primarily CD4+ T cells and elevated numbers of B cells, macrophages, and eosinophils (J:77099)
• enlarged at 11 weeks of age (J:116157)
spleen hyperplasia ( J:116157 )
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
abnormal double-negative T cell morphology ( J:77099 )
• increase in the percentage but not total number of double negative cell in the thymus at 2 weeks of age
decreased double-positive T cell number ( J:77099 )
• reduced percentage and number in the thymus and spleen at 2 weeks of age
increased activated T cell number ( J:77099 )
• most of the CD4+ T cells appear to be activated
• mice contain a higher percentage of proliferating T cells and these cells appear to be resistant to TCR-mediated cell death
abnormal CD4-positive, alpha beta T cell morphology ( J:77099 , J:116157 )
• reduced percentage and number in the thymus and spleen at 2 weeks of age (J:77099)
• increased numbers found in the thymus, spleen and other organs by 4 weeks of age (J:77099)
• about 44% of splenocytes are CD4+ cells (J:116157)
abnormal CD8-positive, alpha beta T cell morphology ( J:77099 )
• reduced percentage and number in the thymus and spleen at 2 weeks of age
increased IgG1 level ( J:77099 )
• increase in IgG1
decreased T cell proliferation ( J:77099 )
• proliferate poorly in response to anti-CD3 stimulation but proliferation in response to phorbol myristate acetate and ionomycin or anti-CD3 and anti-CD28 is similar to wild-type
increased T cell proliferation ( J:77099 )
• T cells proliferate in response to ionomycin alone and in response to IL-2 alone unlike wild-type cells

endocrine/exocrine glands
small thymus ( J:77099 )
• at 2 weeks of age
• in older mice thymi are very small and contain a high of CD4+ T cells and B cells
decreased thymocyte number ( J:77099 )
• reduced to about 5 - 10% of wild-type cell number at 2 weeks of age

growth/size/body
enlarged spleen ( J:77099 , J:116157 )
• at 4 weeks of age (J:77099)
• contains primarily CD4+ T cells and elevated numbers of B cells, macrophages, and eosinophils (J:77099)
• enlarged at 11 weeks of age (J:116157)
spleen hyperplasia ( J:116157 )
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice

cellular
decreased T cell proliferation ( J:77099 )
• proliferate poorly in response to anti-CD3 stimulation but proliferation in response to phorbol myristate acetate and ionomycin or anti-CD3 and anti-CD28 is similar to wild-type
increased T cell proliferation ( J:77099 )
• T cells proliferate in response to ionomycin alone and in response to IL-2 alone unlike wild-type cells




Genotype
MGI:3695389
cx2
Allelic
Composition		 Lattm1.1Lov/Lattm1.1Lov
Lat2tm1Wz/Lat2tm1Wz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Wz mutation (0 available); any Lat2 mutation (19 available)
Lattm1.1Lov mutation (0 available); any Lat mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:116157 )
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
spleen hyperplasia ( J:116157 )
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
abnormal CD4-positive, alpha beta T cell morphology ( J:116157 )
• about 68% of splenocytes are CD4+ cells
enlarged lymph nodes ( J:116157 )
• enlarged at 11 weeks of age
• lymph node size is increased compared to Lat single homozygotes
increased anti-double stranded DNA antibody level ( J:116157 )
• high titers of dsDNA antibodies are present at 6 weeks of age
• titers of dsDNA antibodies are higher and detected earlier than in Lat single homozygotes

hematopoietic system
enlarged spleen ( J:116157 )
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
spleen hyperplasia ( J:116157 )
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
abnormal CD4-positive, alpha beta T cell morphology ( J:116157 )
• about 68% of splenocytes are CD4+ cells

growth/size/body
enlarged spleen ( J:116157 )
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
spleen hyperplasia ( J:116157 )
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory