Phenotypes associated with this allele

• Allele Symbol: Igh^tm3Cgn
• Allele Name: targeted mutation 3, University of Cologne
• Allele ID: MGI:2388492
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm3Cgn/Igh^tm3Cgn	involves: C57BL/6	MGI:3718460
ht2	Igh^tm3Cgn/Igh^+	involves: C57BL/6	MGI:3687256
ht3	Igh^tm2Cgn/Igh^tm3Cgn	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/Ka	MGI:3687257
ht4	Igh^tm1Kplm/Igh^tm3Cgn	involves: C57BL/6	MGI:3693007

Genotype
MGI:3718460

hm1

• Allelic Composition: Igh^tm3Cgn/Igh^tm3Cgn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased immature B cell number ( J:76117 )

• there is a two-fold reduction in immature B cells

• apoptosis levels are increased in immature B cells

abnormal immune system physiology ( J:76117 )

• anti-DNA antibodies are not present in serum

hematopoietic system

decreased immature B cell number ( J:76117 )

• there is a two-fold reduction in immature B cells

• apoptosis levels are increased in immature B cells

Genotype
MGI:3687256

ht2

• Allelic Composition: Igh^tm3Cgn/Igh⁺
• Genetic Background: involves: C57BL/6

immune system

abnormal B cell differentiation ( J:79556 , J:115292 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type (J:79556)

• in 2-4 month old mice, majority of B cells are B-2 cells, expressing high levels of IgD and B220; these cells do not express CD5 which is found on T and B-1 cells (J:115292)

hematopoietic system

abnormal B cell differentiation ( J:79556 , J:115292 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type (J:79556)

• in 2-4 month old mice, majority of B cells are B-2 cells, expressing high levels of IgD and B220; these cells do not express CD5 which is found on T and B-1 cells (J:115292)

Genotype
MGI:3687257

ht3

• Allelic Composition: Igh^tm2Cgn/Igh^tm3Cgn
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/Ka

immune system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

hematopoietic system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

Genotype
MGI:3693007

ht4

• Allelic Composition: Igh^tm1Kplm/Igh^tm3Cgn
• Genetic Background: involves: C57BL/6

hematopoietic system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgnmutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants

immune system

abnormal B cell differentiation ( J:115292 )

• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells

abnormal B cell number ( J:115292 )

• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Igh^tm3Cgn or Igh^tm4Cgnmutants, but peritoneal B cell number is increased, similar to Igh^tm1Kplm mutants