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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm3Cgn
targeted mutation 3, University of Cologne
MGI:2388492
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm3Cgn/Ightm3Cgn involves: C57BL/6 MGI:3718460
ht2
 		Ightm3Cgn/Igh+ involves: C57BL/6 MGI:3687256
ht3
 		Ightm2Cgn/Ightm3Cgn involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/Ka MGI:3687257
ht4
 		Ightm1Kplm/Ightm3Cgn involves: C57BL/6 MGI:3693007


Genotype
MGI:3718460
hm1
Allelic
Composition		 Ightm3Cgn/Ightm3Cgn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Cgn mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased immature B cell number ( J:76117 )
• there is a two-fold reduction in immature B cells
• apoptosis levels are increased in immature B cells
abnormal immune system physiology ( J:76117 )
• anti-DNA antibodies are not present in serum

hematopoietic system
decreased immature B cell number ( J:76117 )
• there is a two-fold reduction in immature B cells
• apoptosis levels are increased in immature B cells




Genotype
MGI:3687256
ht2
Allelic
Composition		 Ightm3Cgn/Igh+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Cgn mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:79556 , J:115292 )
• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type (J:79556)
• in 2-4 month old mice, majority of B cells are B-2 cells, expressing high levels of IgD and B220; these cells do not express CD5 which is found on T and B-1 cells (J:115292)

hematopoietic system
abnormal B cell differentiation ( J:79556 , J:115292 )
• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type (J:79556)
• in 2-4 month old mice, majority of B cells are B-2 cells, expressing high levels of IgD and B220; these cells do not express CD5 which is found on T and B-1 cells (J:115292)




Genotype
MGI:3687257
ht3
Allelic
Composition		 Ightm2Cgn/Ightm3Cgn
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/Ka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cgn mutation (1 available); any Igh mutation (43 available)
Ightm3Cgn mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:79556 )
• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

hematopoietic system
abnormal B cell differentiation ( J:79556 )
• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type




Genotype
MGI:3693007
ht4
Allelic
Composition		 Ightm1Kplm/Ightm3Cgn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (43 available)
Ightm3Cgn mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:115292 )
• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells
abnormal B cell number ( J:115292 )
• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Ightm3Cgn or Ightm4Cgnmutants, but peritoneal B cell number is increased, similar to Ightm1Kplm mutants

immune system
abnormal B cell differentiation ( J:115292 )
• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells
abnormal B cell number ( J:115292 )
• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Ightm3Cgn or Ightm4Cgnmutants, but peritoneal B cell number is increased, similar to Ightm1Kplm mutants




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory