Phenotypes associated with this allele

• Allele Symbol: Tnfrsf13b^tm1Rjb
• Allele Name: targeted mutation 1, Richard J Bram
• Allele ID: MGI:2388136
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf13b^tm1Rjb/Tnfrsf13b^tm1Rjb	involves: 129X1/SvJ	MGI:3840993
hm2	Tnfrsf13b^tm1Rjb/Tnfrsf13b^tm1Rjb	involves: 129X1/SvJ * C57BL/6	MGI:3840972
cx3	Tg(Tnfsf13b)1Fma/? Tnfrsf13b^tm1Rjb/Tnfrsf13b^tm1Rjb	B6.Cg-Tnfrsf13b^tm1Rjb Tg(Tnfsf13b)1Fma	MGI:3841116

Genotype
MGI:3840993

hm1

• Allelic Composition: Tnfrsf13b^tm1Rjb/Tnfrsf13b^tm1Rjb
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:95288 )

• B cells fail to induce class switch recombination in response to Tnfsf13 (APRIL) ligand

decreased IgA level ( J:95288 )

• B cells fail to produce IgA immunoglobulins in response to Tnfsf13 or Tnfsf13b ligands

• synthesize of IgA in response to LPS and TGF-beta is normal

decreased IgE level ( J:95288 )

• B cells fail to produce IgE immunoglobulins in response to Tnfsf13 ligand

• synthesize of IgE in response to LPS and IL-4 is normal

decreased IgG1 level ( J:95288 )

• B cells fail to produce IgG1 immunoglobulins in response to Tnfsf13 ligand

• synthesize of IgG1 in response to LPS and IL-4 is normal

hematopoietic system

abnormal class switch recombination ( J:95288 )

• B cells fail to induce class switch recombination in response to Tnfsf13 (APRIL) ligand

decreased IgA level ( J:95288 )

• B cells fail to produce IgA immunoglobulins in response to Tnfsf13 or Tnfsf13b ligands

• synthesize of IgA in response to LPS and TGF-beta is normal

decreased IgE level ( J:95288 )

• B cells fail to produce IgE immunoglobulins in response to Tnfsf13 ligand

• synthesize of IgE in response to LPS and IL-4 is normal

decreased IgG1 level ( J:95288 )

• B cells fail to produce IgG1 immunoglobulins in response to Tnfsf13 ligand

• synthesize of IgG1 in response to LPS and IL-4 is normal

Genotype
MGI:3840972

hm2

• Allelic Composition: Tnfrsf13b^tm1Rjb/Tnfrsf13b^tm1Rjb
• Genetic Background: involves: 129X1/SvJ * C57BL/6

immune system

increased spleen weight ( J:69474 )

• spleen weight is almost double that of controls

increased B cell number ( J:69474 )

• B cell numbers are about twice that of controls in the spleen and blood

abnormal B cell activation ( J:69474 )

• B cells have defects in T-cell independent type II (TI-II) humoral response

• antigen-specific IgM secretion in response to immunization with two different TI-II antigens is one-third to one-fifth less than controls

• secretion of IgG class immuglobulins is reduced by a fifth when immunized to a TI-II antigen

• varying the dose of antigen fails to rescue the humoral defect

increased B cell proliferation ( J:69474 )

• splenic IgM^loIgD^hi B cells have a higher rate of proliferation compared to controls

decreased IgA level ( J:69474 )

• circulating IgA levels are decreased

decreased IgM level ( J:69474 )

• circulating IgM levels are decreased

hematopoietic system

increased spleen weight ( J:69474 )

• spleen weight is almost double that of controls

increased B cell number ( J:69474 )

• B cell numbers are about twice that of controls in the spleen and blood

abnormal B cell activation ( J:69474 )

• B cells have defects in T-cell independent type II (TI-II) humoral response

• antigen-specific IgM secretion in response to immunization with two different TI-II antigens is one-third to one-fifth less than controls

• secretion of IgG class immuglobulins is reduced by a fifth when immunized to a TI-II antigen

• varying the dose of antigen fails to rescue the humoral defect

increased B cell proliferation ( J:69474 )

• splenic IgM^loIgD^hi B cells have a higher rate of proliferation compared to controls

decreased IgA level ( J:69474 )

• circulating IgA levels are decreased

decreased IgM level ( J:69474 )

• circulating IgM levels are decreased

cellular

increased B cell proliferation ( J:69474 )

• splenic IgM^loIgD^hi B cells have a higher rate of proliferation compared to controls

growth/size/body

increased spleen weight ( J:69474 )

• spleen weight is almost double that of controls

Genotype
MGI:3841116

cx3

• Allelic Composition: Tg(Tnfsf13b)1Fma/?; Tnfrsf13b^tm1Rjb/Tnfrsf13b^tm1Rjb
• Genetic Background: B6.Cg-Tnfrsf13b^tm1Rjb Tg(Tnfsf13b)1Fma

hematopoietic system

abnormal class switch recombination ( J:113556 )

• class switch recombination mediated by T cell independent antigens is defective in these mice

immune system

abnormal class switch recombination ( J:113556 )

• class switch recombination mediated by T cell independent antigens is defective in these mice