All Phenotypes Rxfp2<tm1Aia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rxfp2^tm1Aia
targeted mutation 1, Alexander I Agoulnik
MGI:2388129

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rxfp2^tm1Aia/Rxfp2^tm1Aia	involves: 129S7/SvEvBrd	MGI:5473316
hm2	Rxfp2^tm1Aia/Rxfp2^tm1Aia	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2388134
cn3	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Rarb-cre)1Bhr/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL	MGI:5473318
cn4	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL	MGI:5473320
cn5	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(ACTA1-cre)79Jme/0	involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N * SJL	MGI:5473317
cn6	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Stra8-icre)1Reb/0	involves: 129S7/SvEvBrd * C57BL/6N * FVB/NJ	MGI:5473319
cx7	Rxfp1^tm1Aia/Rxfp1^tm1Aia Rxfp2^tm1Aia/Rxfp2^tm1Aia	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3054971
cx8	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:5141501
cx9	Rxfp2^tm1Aia/crsp	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:3603529

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^tm1Aia
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

reproductive system

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^tm1Aia
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

reproductive system

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

arrest of spermatogenesis ( J:79124 )

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

abnormal inguinal canal morphology ( J:79124 )

• inguinal canal fails to form

male infertility ( J:79124 )

endocrine/exocrine glands

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

skeleton

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:79124

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Rarb-cre)1Bhr/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)
Rxfp2^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Rxfp2 mutation (54 available)
Tg(Rarb-cre)1Bhr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

endocrine/exocrine glands

cryptorchism ( J:194006 )

• high intra-abdominal cryptorchidism

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:194006 )

N	• mice exhibit normal testis position

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(ACTA1-cre)79Jme/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N * SJL

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:194006 )

N	• mice exhibit normal testis position

Allelic Composition	Rxfp2^tm1Aia/Rxfp2^{tm1c(EUCOMM)Wtsi} Tg(Stra8-icre)1Reb/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6N * FVB/NJ

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:194006 )

N	• mice exhibit normal reproductive organ abnormalities

Allelic Composition	Rxfp1^tm1Aia/Rxfp1^tm1Aia Rxfp2^tm1Aia/Rxfp2^tm1Aia
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxfp1^tm1Aia mutation (0 available); any Rxfp1 mutation (53 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased nipple size ( J:92627 )

• mutant females have small nipples

cryptorchism ( J:92627 )

• intra-abdominal cryptorchism is seen

• 1 male (out of 11) showed unilateral torsion of the cryptorchid testis with hemorrhage and necrosis and 2 others were missing the right testis probably as a result of necrosis following torsion

abnormal lactation ( J:92627 )

• about 2/3 of the mutant females are unable to nurse pups

reproductive system

cryptorchism ( J:92627 )

• intra-abdominal cryptorchism is seen

• 1 male (out of 11) showed unilateral torsion of the cryptorchid testis with hemorrhage and necrosis and 2 others were missing the right testis probably as a result of necrosis following torsion

respiratory system

respiratory system phenotype ( J:92627 )

N	• no significant fibrosis is seen in the lungs

integument

decreased nipple size ( J:92627 )

• mutant females have small nipples

abnormal lactation ( J:92627 )

• about 2/3 of the mutant females are unable to nurse pups

Allelic Composition	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1^tm1.1Aia mutation (0 available); any Cav1 mutation (33 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:174719 )

N	• female mice are fertile

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

abnormal uterus physiology ( J:174719 )

• endometrial glandular epithelium in mice with cysts exhibit increased proliferation compared to in wild-type mice

neoplasm

neoplasm ( J:174719 )

N	• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

growth/size/body

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

Allelic Composition	Rxfp2^tm1Aia/crsp
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
crsp mutation (0 available); any crsp mutation (0 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

reproductive system

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

arrest of spermatogenesis ( J:79124 )

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

absent male inguinal canal ( J:79124 )

• inguinal canal fails to form

male infertility ( J:79124 )

endocrine/exocrine glands

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

skeleton

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:79124

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