Phenotypes associated with this allele

• Allele Symbol: Nid2^{Gt(GST011)Byg}
• Allele Name: gene trap GST011, BayGenomics
• Allele ID: MGI:2388069
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nid2^Gt(GST011)Byg/Nid2^Gt(GST011)Byg	involves: 129P2/OlaHsd	MGI:3513336
cx2	Nid1^tm1Ron/Nid1^tm1Ron Nid2^Gt(GST011)Byg/Nid2^Gt(GST011)Byg	involves: 129P2/OlaHsd	MGI:3701474

Genotype
MGI:3513336

hm1

• Allelic Composition: Nid2^{Gt(GST011)Byg}/Nid2^{Gt(GST011)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

osteoarthritis ( J:229684 )

skeleton

osteoarthritis ( J:229684 )

abnormal cartilage morphology ( J:229684 )

• wider zone of calcified cartilage in young mice

• calcium phosphate crystals in the extracellular matrix of cartilage right above the tidemark are increased

abnormal hyaline cartilage morphology ( J:229684 )

• hyaline cartilage of knee joints exhibits signs of early calcification

calcified joint ( J:229684 )

• 9 week old mice exhibit decreased toluidine blue staining in the deeper zones of joint surfaces, indicating calcified cartilage

• hyaline cartilage of knee joints exhibits signs of early calcification

• 24 week old mice exhibit a highly reduced proteoglycan content in the calcified cartilage adjacent to the subchondral bone and in the remaining articular cartilage

cellular

cellular phenotype ( J:78947 )

N • histology and basement membrane formation appeared normal in deficient tissues

Genotype
MGI:3701474

cx2

• Allelic Composition: Nid1^tm1Ron/Nid1^tm1Ron; Nid2^{Gt(GST011)Byg}/Nid2^{Gt(GST011)Byg}
• Genetic Background: involves: 129P2/OlaHsd

cellular

abnormal cell physiology ( J:119014 )

• in 3D cocultures, mutant fibroblasts show defective basement membrane formation