Analysis Tools
mortality/aging
|
• homozygotes are never observed after birth
|
|
Allele Symbol Allele Name Allele ID |
Fgfr3tm1.1Iwa targeted mutation 1.1, Tomoko Iwata MGI:2388062 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygotes are never observed after birth
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no homozygotes are found after birth, indicating lethality during gestation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• exhibit abnormal chondrocyte proliferation, with increased proliferation during embryo development but decreased proliferation in the postnatal growth plate chondrocytes
|
|
• one set of mutants (52%) that are very small, die 4 weeks after birth
• 24% of mildly affected mutants live longer than 3 months, including some up to as long as wild-type
• Background Sensitivity: on a CD background, about 46% that are severely affected die early while 14% live longer than 3 months
|
|
• seen in severely affected mice, although some several severely affected mice die without malocclusion
|
|
• distinguishable at birth by a mildly round head
|
|
• those that die 4 weeks after birth are very small
|
|
• enlarged hyoid bone
|
|
• seen in severely affected mice, although some several severely affected mice die without malocclusion
|
|
• distinguishable at birth by a mildly round head
|
|
• shorter limbs with particularly shortened ossified zone
|
|
• exhibit abnormal chondrocyte proliferation, with increased proliferation during embryo development but decreased proliferation in the postnatal growth plate chondrocytes
|
|
• enlarged hyoid bone
|
|
• seen in severely affected mice, although some several severely affected mice die without malocclusion
|
|
• wider and shorter limb long bones
|
|
• delay in sternabrae ossification at P1
|
|
• thickening and slight bifurcation of the costal cartilage is seen at P1 and at 15 months of age
• at 15 months of age, observe clonal proliferation of chondrocytes in costal cartilage
• thinner layer of perichondrium in costal cartilage
|
|
• smaller rib cage is evident after P4
|
|
• exhibit curvature of the axial skeleton
|
|
• chondrocytes in the medial part of the femur are smaller and premature at E15.5
• chondrocytes around the blood vessel in epiphysis are smaller at P4
|
|
• decrease in chondrocyte differentiation
|
|
• overgrowth of hyaline cartilage, including the trachea and the nasal septa and hypertrophy of the thyroid, cricoid, and tracheal cartilages
|
|
• growth plates at the junctions of the rib-bone and the costal cartilage at P17 are abnormal
|
|
• exhibit ingrowth of mesenchymal tissue across the physis at P17
• some undifferentiated chondrocytes intermingle with the hypertrophic chondrocytes at E15.5
• thicker growth plate with shorter hypertrophic zones and proliferating columns at P17
|
|
• chondrocytes have shorter columnar structures of the proliferating zone
|
|
• hypertrophic chondrocytes are sparse and not fully mature
|
|
• delay formation of the secondary ossification center
• delay in sternabrae ossification at P1
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal dominant disease | DOID:0050736 | J:70061 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/14/2024 MGI 6.23 |
|
|
|
||