Phenotypes associated with this allele

• Allele Symbol: Blm^tm1Grdn
• Allele Name: targeted mutation 1, Joanna Groden
• Allele ID: MGI:2388038
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Blm^tm1Grdn/Blm^+	involves: 129P2/OlaHsd * Black Swiss	MGI:3582673
cx2	Apc^Min/Apc^+ Blm^tm1Grdn/Blm^+	involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J	MGI:3582674

Genotype
MGI:3582673

ht1

• Allelic Composition: Blm^tm1Grdn/Blm⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of induced tumors ( J:79058 )

• enhanced T cell tumorigenesis in response to viral challenge with murine leukemia virus, with heterozygous mutant mice exhibiting a shorter life-span than wild-type mice (117 days vs. 184 days in wild-type)

cellular

chromosome breakage ( J:79058 )

• two-fold increase in the number of micronuclei in lung fibroblasts, indicating an increase in genomic instability

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bloom syndrome		DOID:2717	OMIM:210900	J:79058

Genotype
MGI:3582674

cx2

• Allelic Composition: Apc^Min/Apc⁺; Blm^tm1Grdn/Blm⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

neoplasm

increased gastrointestinal tumor incidence ( J:79058 )

• developed twice as many gastrointestinal adenomas as single heterozygous Apc mutant mice (31.4 tumors/mouse vs. 14.2 tumors/mouse in wildtype), however tumors were similar in size

increased intestinal adenoma incidence ( J:79058 )

• developed low- and high-grade adenomas in the small intestine, whereas only low-grade adenomas were seen in heterozygous Apc mutant mice

increased colon adenoma incidence ( J:79058 )

• all colonic adenomas displayed high-grade dysplasia

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:79058 )

• developed twice as many gastrointestinal adenomas as single heterozygous Apc mutant mice (31.4 tumors/mouse vs. 14.2 tumors/mouse in wildtype), however tumors were similar in size

increased intestinal adenoma incidence ( J:79058 )

• developed low- and high-grade adenomas in the small intestine, whereas only low-grade adenomas were seen in heterozygous Apc mutant mice

increased colon adenoma incidence ( J:79058 )

• all colonic adenomas displayed high-grade dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bloom syndrome		DOID:2717	OMIM:210900	J:79058