Phenotypes associated with this allele

• Allele Symbol: Kif1b⁺
• Allele Name: wild type
• Allele ID: MGI:2387928
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kif1b^tm1b(KOMP)Wtsi/Kif1b^+	C57BL/6N-Kif1b^tm1b(KOMP)Wtsi/J	MGI:5631239
ht2	Kif1b^tm1Noh/Kif1b^+	involves: 129S4/SvJae * C57BL/6J	MGI:2387931

Genotype
MGI:5631239

ht1

• Allelic Composition: Kif1b^{tm1b(KOMP)Wtsi}/Kif1b⁺
• Genetic Background: C57BL/6N-Kif1b^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0624_1_H07

Data Sources

IMPC Data for Kif1b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - JAX

decreased thigmotaxis ( J:211773 )

IMPC - JAX

increased startle reflex ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

♀

IMPC - JAX

increased vertical activity ( J:211773 )

♀

IMPC - JAX

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

decreased blood urea nitrogen level ( J:211773 )

♀

IMPC - JAX

increased circulating sodium level ( J:211773 )

IMPC - JAX

increased circulating chloride level ( J:211773 )

♀

IMPC - JAX

Genotype
MGI:2387931

ht2

• Allelic Composition: Kif1b^tm1Noh/Kif1b⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

behavior/neurological

abnormal motor coordination/balance ( J:69772 )

• staggering; onset at approximately one year of age; progressive

impaired coordination ( J:69772 )

• at 12 months of age, impairment was observed in a rotarod test and a balance beam test

muscle

progressive muscle weakness ( J:69772 )

• at 12 months of age, evoked compound action potential amplitudes were significantly reduced; the conduction velocity was unaffected

nervous system

abnormal axonal transport ( J:69772 )

• impaired vesicle transport in peripheral nerves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease type 2A1		DOID:0110154	OMIM:118210	J:69772