Phenotypes associated with this allele

• Allele Symbol: Cacna1b^tm1Ttan
• Allele Name: targeted mutation 1, Tsutomu Tanabe
• Allele ID: MGI:2387803
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1b^tm1Ttan/Cacna1b^tm1Ttan	involves: 129S4/SvJae * C57BL/6	MGI:3625851

Genotype
MGI:3625851

hm1

• Allelic Composition: Cacna1b^tm1Ttan/Cacna1b^tm1Ttan
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:69585 )

• ~30% of the homozygous mice were lost prior to weaning age

• surviving mice appear normal and survive to adulthood without any apparent motor dysfunction

nervous system

nervous system phenotype ( J:69585 )

N • measures of sympathetic nervous system function did not differ between mutant and control mice; peripheral body temperature, resting heart rate and blood pressure are similar in mutant and control mice

abnormal excitatory postsynaptic potential ( J:107971 )

• field EPSPs at Schaffer collateral-CA1 synapses in hippocampal slices are depressed by halothane in mutants; depression is concentration dependent, reversible and greater in mutants than wild-type

behavior/neurological

abnormal behavioral response to xenobiotic ( J:107971 )

• when halothane is used, homozygotes show a lower EC50 for the minimum alveolar concentration (MAC) for loss of the righting reflex; EC50 for the MAC needed for loss of tail pinch response is also lower in mutants

• sleep time after intravenous injection of propofol is shorter in mutants than in wild-type

decreased anxiety-related response ( J:69585 )

• in an elevated plus-maze test, mutant mice enter and spend more time in the open arms than controls

• sin an open-field test, mutant mice travel a longer total distance than controls

hyporesponsive to tactile stimuli ( J:69585 )

• mutant mice show a prolonged latency in a tail flick test compared to controls

• no differences in latency is detectable in a paw flick or hot plate test between the mutant and control mice

• responses to acute mechanical stimuli by the tail pressure test or using von Frey filaments were not different between the mutant and control mice

decreased startle reflex ( J:69585 )

• at acoustic stimuli of 115 and 120 dB, mutant mice exhibit reduced responses compared to controls

increased chemical nociceptive threshold ( J:69585 )

• the biphasic pain response of mutant mice exhibit significantly attenuated response in the early part of Phase 2, but normal pain behaviors are seen in Phase 1 when hindpaws are injected with 2% formalin; the level of swelling associated with injection of formalin is similar in mutant mice and controls, indicating that reduced pain responses are not due to reduced inflammation

• the stretching/writhing motion response to visceral inflammatory pain caused by injection of 0.6% acetic acid into the peritoneal cavity is reduced in similar in control and mutant mice